【摘要】 目的分析研究2型糖尿病(T2DM)住院患者合并甲状腺功能异常的患病情况。方法回顾性分析我院内分泌科住院诊治的158例临床资料齐全的T2DM患者,根据患者的甲状腺功能将其分为研究组(T2DM并甲状腺功能异常,48例)和对照组(T2DM并甲状腺功能正常,110例)。统计两组患者的性别、年龄、体重指数(BMI),检测甲状腺自身抗体、血糖、糖化血红蛋白、C肽、血脂水平。结果 158例患者中,研究组占30.4%,对照组占69.6%。研究组中,以亚临床型甲减发病率最高,占52.1%;女性甲状腺功能异常发病率明显高于男性(P<0.05)。研究组年龄、FCP、2 hCP、TG、TPOAb及TgAb明显高于对照组(P<0.05)。两组BMI、血糖、HbA1c、TC、LDL-C、HDL-C无显著差异(P>0.05)。结论 T2DM患者易并发甲状腺功能异常,主要表现为甲减,且好发于高龄女性,临床上应注意监测甲状腺各项功能指标,提高临床诊断率,避免误诊漏诊。更多还原

【Abstract】 Objective To investigate the prevalence situation of abnormal thyroid function in hospitalized patients with type 2 diabetes mellitus(T2DM). Methods The clinical data of 158 cases of patients with T2DM treated in our hospital were analyzed retrospectively. All the patients were divided into research group(diabetes mellitus complicated with thyroid dysfunction, 48 cases) and control group(diabetes mellitus complicated with thyroid function,110 cases) according to the thyroid function. The gender, age, body mass index(BMI), levels of thyroid autoantibodies, blood glucose,hemoglobin A1c(HbA1c), plasma C-peptide, blood fat thyroid autoantibodies in the two groups were calculated and analyzed. Results There was 30.4% in the research group, and 69.6% in the control group in 158 patients. In the research group, 52.1% with subclinical hypothyroidism was the highest morbidity; the incidence of thyroid dysfunction in women was significantly higher than that in men(P<0.05). The age, FCP, 2 hCP, TG, TPOAb and Tg Ab of the research group were significant higher than those in the control group(P <0.05). The BMI, blood glucose, HbA1c、TC、LDL-C、HDL-C of the two groups had no statistically significant difference(P >0.05). Conclusion T2DM patients are easily complicated with abnormal thyroid function extremely, the main manifestation is hypothyroidism, older female patients has higher incidence. Clinical attention should be paid to monitoring various thyroid functional indicators, improve the clinical diagnosis rate, avoid misdiagnosis missed diagnosis.更多还原