【摘要】 目的探讨T淋巴细胞亚群变化对脑卒中相关性肺炎(SAP)的预测价值。方法收集脑卒中发病24h内入院患者57例,根据脑卒中发生7d内是否发生肺炎分为SAP组和非SAP组,分别于卒中发病24h内及7d时完成T淋巴细胞亚群检测。探索SAP发生的独立预测因素,并使用受试者工作特征曲线评估(ROC)其对SAP的预测价值。结果脑卒中发病24h内外周血CD3+、CD4+、CD4+/CD8+T淋巴细胞水平均低于对照组,差异有统计学意义(P<0.05)。脑卒中7d后以上各值均较发病24h内升高,非SAP组升高较SAP组明显(P<0.05)。结论脑卒中早期CD4+T淋巴细胞计数下降对SAP的发生具有预测价值。更多还原

【Abstract】 Objective To investigate the predictive value of T lymphocyte subsets in stroke-associated pneumonia(SAP). Method The patients with actue stroke admitted to hospital within 24 hours after symptom onset. 57 cases were recruited as the research objects. They were divided into the SAP group and non-SAP group according to whether they had SAP or not within one weeks after symptom onset. The peripheral venous blood were tested T lymphocyte subsets within 24 hours of onset and 7 days respectively. To explore the independent predictive factors of SAP, use the receiver operating characteristic to evaluate the predictive value of SAP. Results The SAP group CD3+, CD4+, CD4+/CD8+T lymphocyte levels were lower than non SAP group, the difference was statistically significant(P<0.05). CD3+, CD4+, CD4+/CD8+T lymphocyte level in experimental groups were elevated after 7 days of stroke than that of within 24 hours stroke onset, non-SAP group increased significantly compared with that of SAP group(P<0.05). Conclusion CD4+T lymphocyte count decreased early stroke have predictive value for the occurrence of SAP.更多还原