【摘要】 目的分析、比较广西地区汉族与壮族人群X-STR基因座的分布频率及遗传学参数。方法应用Investigator A r g u sX-12试剂对广西地区1267名健康成年人进行D X S 8378等12个X-S T R分型检测,其中612名汉族作为对照组,另外655名壮族作为研究组,比较两组间基因座的分布频率以及基因座遗传学参数。结果①两组等位基因分布均符合HardyWeinberg平衡,其中汉族检测出128种基因型,基因分布频率为0.0029～0.7872,壮族检测出145种基因型,基因分布频率为0.003 5～0.658 1。②对照组汉族的多态信息量分布为0.388 6～0.896 6,研究组壮族的多态信息量分布为0.405 9～0.889 3;对照组汉族的杂合度分布为0.3796～0.8091,研究组壮族的杂合度分布为0.5018～0.8255;对照组MECduo与MECtrio的分布频率为0.3677～0.6850与0.4357～0.8421,研究组MECduo与MECtrio的分布频率为0.4233～0.8217与0.4755～0.9128;对照组个体识别力及非父排除率分别为0.5558～0.8722与0.4711～0.8227,研究组的个体识别力及非父排除率分别为0.7874～0.9781与0.5201～0.8647。结论广西地区汉族与壮族的X-STR基因座分布均符合Hardy-Weinberg平衡,但是壮族的X-STR基因座呈现出高度多态性,与汉族有较多差别,对于本地区法医亲权鉴定具有一定的指导意义。更多还原

【Abstract】 Objective To obtain genetic parameters of X-STR loci,we analysed and compared the distribution frequency in Han population and Zhuang population in Guangxi province. Methods 1 267 healthy adults in Guangxi were detected with twelve X-STR’s subtypes such as DXS 8378 by Investigator Argus X-12 KIT. 612 cases Han population were regarded as the control group and 655 cases Zhuang population as the study group. Genotype distribution frequency and genetic parameters of the two groups were compared. Results(1)Genotype distribution frequency of two groups were all consistent with Hardy-Weinberg equilibrium. 128 genotypes were detected in Han population and genotype distribution frequency was 0.002 9～0.787 2. 145 genotypes was detected in Zhuang population and genotype distribution frequency were 0.003 5～0.658 1.(2)The PIC of Han population was 0.388 6～0.896 6 and the PIC of Zhuang population was 0.405 9～0.8893.The Heterozygosity of Han population was 0.379 6～0.809 1 and the Heterozygosity of Zhuang population was 0.501 8～0.8255. The MECduo and MECtrio of Han population was 0.367 7～0.685 0 and 0.4357～0.8421,and the MECduo and MECtrio of Zhuang population was 0.423 3～0.821 7 and 0.475 5～0.912 8. The DP and EP of Han population was 0.555 8～0.872 2 and 0.471 1～0.822 7,and the DP and EP of Zhuang population was 0.787 4～0.978 1 and 0.520 1～0.864 7. ConclusionsGenotype distribution frequency of two groups are all consistent with Hardy-Weinberg equilibrium. But the X-STR loci in Zhuang population are highly polymorphic,which is different from that of Han population. It has certain guiding significance for paternity identification in forensic medicine in this region.更多还原