【摘要】 目的 探讨不同年龄、性别及不同季节健康成年人群的维生素D（VD）营养状况。方法 选取2016年1月1日～12月31日于我院体检中心完成体格检查且肝肾功能正常的健康成人9 997例,检测其血清25-羟维生素D₃ [25 （OH） D₃]浓度。分别定义血清25（OH） D₃≥30 ng/ml、20～30 ng/ml与≤20 ng/ml为VD正常、不足与缺乏。将年龄≤44岁、45～59岁、≥60岁分别定义为青年、中年及老年。所有研究对象根据性别及年龄进行分组,分别统计各组血清25 （OH） D₃浓度及VD正常、不足、缺乏者的百分比并进行比较。按月份分别统计VD正常、不足及缺乏的例数。结果 总体人群、男性组及女性组VD正常者所占百分比分别为18.3%、23. 8%及10.1%,VD不足者分别为38.5%、40.9%及34.8%,VD缺乏者分别为43.2%、35.3%及55.1%;男性组VD缺乏和不足的整体占比低于女性组（P<0.001）。青年、中年和老年组VD不足者所占百分比分别为37.0%、40.0%及40.0%,VD缺乏者分别为45. 0%、42.1%及36.6%;青、中年VD缺乏及不足的整体占比高于老年人群（P <0.001）。男性组血清25 （OH） D₃浓度为（24.15±8.77） ng/ml,明显高于女性组[（20.06±7.55）ng/ml,P<0.001]。青年组、中年组、老年组的血清25（OH）D₃浓度分别为（22.31±8.54）ng/ml、（22.49±8.32）ng/ml、（24.00±9.56）ng/ml,老年组血清25（OH）D₃浓度高于青年组及中年组（P<0.001）。VD缺乏率2月最高（75.9%）,10月最低（26.9%）。结论 VD不足和缺乏在健康成年人群中较普遍,尤其在≤44岁人群及女性中;而2月份VD缺乏更加严重。更多还原

【Abstract】 Objective To explore the nutritional status of vitamin D（VD） in healthy adults of different ages,sexes and in different seasons.Methods A total of 9 997 healthy examinees with normal liver and kidney function were included.The levels of 25（OH）D₃ were detected.Serum 25（OH）D₃ ≥30 ng/ml,20-30 ng/ml and ≤ 20 ng/ml were defined as VD normal, insufficiency and deficiency.According to the age ≤44,45-59 and ≥60 years old,people were divided into youth group,middle-age group and old-age group.Subjects were grouped according to gender and age.The concentrations of serum 25（OH）D₃ and the percentages of VD normal, insufficiency and deficiency in all groups were recorded and compared.The rates of VD normal, insufficiency and deficiency were also measured by month.Results The percentages of VD normal in all participants,male group and female group were 18.3%,23.8% and 10.1%.The percentages of VD insufficiency in three groups were 38.5%,40.9% and 34.8%.While the percentages of VD deficiency were 43.2%,35.3% and 55.1%.The overall probability of VD insufficiency and deficiency in males was lower than that in females（P < 0.001）.In the youth, middle-age and old-age groups,the percentages of VD insufficiency were 37.0%,40.0% and 40.0%.The percentages of VD deficiency in three groups were 45.0%,42.1% and 36.6%.The overall probability of VD insufficiency and deficiency in the youth and middle-aged groups was higher than that in the old-aged group（P <0.001）.Serum 25（OH）D₃ concentration of male group was（24.15 ±8.77）ng/ml,which was apparently higher than that in female group[（20.06 ± 7.55） ng/ml, P < 0.001 ].25（OH） D₃ concentrations in the youth,middle-age and old-age groups were（22.31 ±8.54）ng/ml,（22.49 ±8.32）ng/ml and（24.00 ±9.56）ng/ml,and it was higher in old-age group than those in youth group and middle-age group（P < 0.001）.The percentage of VD deficiency was highest in February（75.9%） and lowest in October（26.9%）.Conclusion VD insufficiency and deficiency were common in health adults,especially in people≤44 years old and in females.VD deficiency was more serious in February.更多还原