【摘要】 发展了一种从3-(2-溴代苯甲酰基)-吲哚出发在无过渡金属参与下合成茚并吲哚酮类化合物的新方法。在甲苯/四氢呋喃(2∶1)混合溶剂中,3-(2-溴代苯甲酰基)-吲哚、正丁基锂和碘化锌原位生成的2-吲哚锌在碘化锂辅助下与芳基溴化物发生分子内加成-环化反应,合成了一系列取代的茚并-[1,2-b]吲哚-10(5H)-酮类化合物,且均获得了较好的收率。考察了溶剂、卤化锌、添加剂对产率的影响。更多还原

【Abstract】 A convenient method for the preparation of indenoindolones from 3-( 2-bromobenzoyl)-indoles without the aid of transition-metal catalysis has been developed. 2-Zincioindole reagents,prepared in-situ from 3-( 2-bromobenzoyl)-indoles,n-Bu Li and Zn I2,were found to undergo intramolecular addition-cyclizing reactions with aryl bromides in the presence of Li I in a mixed solvent consisting of toluene and THF( 2∶ 1). Various substituted indeno[1,2-b]indol-10( 5 H)-ones can be obtained in good yields. The effects of reaction parameters such as solvent,zinc halide and additive on the yield were investigated.更多还原