【摘要】 目的分析深圳、东莞地区抗甲状腺球蛋白抗体(anti-Tg)、抗线粒体抗体M2亚型抗体(AMA-M2)、抗环瓜氨酸肽抗体(anti-CCP)、抗双链DNA抗体(anti-ds DNA)、胰岛素自身抗体(IAA)和Anti-Sm/Anti-U1-RNP的水平和分布。方法收集深圳、东莞2014年1月至2017年1月来医院进行体检的110 068例人群为研究对象。结果 110 068例体检者中AntiTg、AMA-M2、Anti-CCP、Anti-ds DNA、IAA和Anti-Sm/Anti-U1-RNP阳性者分别为1 698(1.54%)、25例(0.02%)、425例(0.39%)、10例(0.01%)、1 873例(1.70%)和25例(0.02%),女性自身抗体阳性高于男性,31~60岁自身抗体阳性表达较高,体重指数越高,城市居民、文化程度越高、家庭收入越高和离异者的Anti-Tg、AMA-M2和IAA阳性越高(P<0.05)。结论深圳、东莞地区的6种自身抗体均有不同程度的阳性人群,女性自身抗体阳性较高,31~60岁,体重指数较高、文化程度较高、城市居民和离异是自身抗体阳性高发人群。更多还原

【Abstract】 Objective To analyze the expression and distribution trend of thyroglobulin antibody( Anti-Tg),anti-mitochondrial antibodies-M2( AMA-M2),anti-cyclic citrullinated peptide antibodies( Anti-CCP),anti-double stranded DNA( Anti-ds DNA),insulin autoimmune antibody( IAA) and Anti-Sm/Anti-U1-RNP autoantibodies in Shenzhen and Dongguan District. Methods Data of 1,10068 cases for physical examination in our hospital from January 2014 to January 2017 were collected analyzed. Results Anti-Tg、AMA-M2、Anti-CCP、Anti-ds DNA、IAA and Anti-Sm/Anti-U1-RNP1698( 1. 54%),25( 0. 02%),425( 0. 39%),10( 0. 01%),1 873( 1. 702%) and 25( 0. 02%),Among the 110 068 cases,the number of positive was: Anti-Tg 1698( 1. 54%) 、AMA-M2 25( 0. 02%) 、Anti-CCP 425( 0. 39%) 、Anti-ds DNA 10( 0. 01%) 、IAA 1873( 1. 70%) and Anti-Sm/Anti-U1-RNP 25( 0. 02%). Positive autoantibodies of female were higher than male. The 31-60 age group had higher positive autoantibody. Those with higher body index,urban residents,with higher education and higher family income and divorced,the above personnel had higher positive Anti-Tg、AMA-M2 and IAA( P < 0. 05). Conclusion Six kinds of autoantibodies had different levels of positive population in Shenzhen and Dongguan District,female had higher positive autoantibodies. The 31-60 age group,those with higher body index,the higher education group,the urban residents and the divorced were the high incidence population of autoantibody positive.更多还原