【摘要】 目的:分析研讨不同活性促甲状腺素受体抗体(TRAb)的Graves病患者抗甲状腺药物治疗后甲亢复发率差异。方法:随机从我院2015年3月~2017年5月收治的Graves病患者中抽取100例纳入到讨论中,测定甲状腺指标、抗甲状腺过氧化物酶抗体(TPO-Ab)、抗甲状腺球蛋白抗体(TG-Ab)、TRAb等,按照首次TRAb不同滴度进行分组,低活性组(56例)、中活性组(31例)、高活性组(13例)。患者均接受抗甲状腺药物治疗后,直至TRAb指标转阴停药并观察,记录比较甲亢复发率。结果:对比治疗前三组TPO-Ab、TG-Ab、FT4、FT3、TSH指标,高活性组TRAb、TPO-Ab、TG-Ab、FT4、FT3高于中活性组、低活性组,且P<0.05;对比三组TSH指标,P>0.05。治疗后,对比三组TRAb指标,高活性组高于中活性组、低活性组,且P<0.05,中活性组也高于低活性组,且P<0.05。高活性组TPO-Ab指标也高于中活性组、低活性组,且P<0.05。高活性组疾病复发率38.46%高于中活性组的12.90%、低活性组的7.14%,中活性组12.90%高于低活性组的7.14%,且P<0.05。结论:TRAb指标不仅可较为准确地反映Graves病情状况,而且可用于判定疾病是否复发。而TRAb高活性Graves病患者接受抗甲状腺药物治疗后,疾病复发率高于中活性和低活性者,因此,临床在治疗时需将高活性疗程适当延长。更多还原

【Abstract】 Objective:To study the difference of the recurrence rate of hyperthyroidism in graves patients with different activity of TSH receptor antibody(TRAB)after anti-thyroid drugs. Methods:100 cases of graves patients admitted to our hospital from March 2015 to May 2017 were randomly taken into the discussion,the thyroid index,anti thyroid peroxidase antibody(tpo-ab),anti thyroid globulin antibody(TG-AB)and Trab were measured. According to the first trab of different drops of group,low active group(56 cases),active group(31 cases),High active group(13 cases). Patients were treated with anti-thyroid drugs,until the Trab index turned yin after stopping the drug and observation,records compare hyperthyroidism recurrence rate. Results:the indexes of TPO-Ab,TG-Ab,FT4,FT3 and TSH were compared between the three groups before treatment. The high activity group TRAb,TPO-Ab,TG-Ab,FT4 and FT3 were higher than those of the middle activity group and the low activity group,and P <0.05,compared with the three groups of the index. After treatment,the three groups of TRAb indexes were compared. The high activity group was higher than the medium active group and the low activity group,and the active group was also higher than the low active group,and the activity group was also higher than the low active group,and P<0.05. The TPO-Ab index of the high active group was also higher than that of the middle active group and the low active group,and P<0.05. The recurrence rate of the disease in the high activity group was 38.46% higher than that in the middle active group 12.90%,the low activity group 7.14%,the medium active group 12.90% was higher than the low activity group7.14%,and P<0.05. Conclusion:the TRAb index can not only reflect the condition of Graves more accurately,but also can be used to determine the recurrence of the disease. TRAb high activity Graves disease patients after receiving antithyroid drugs treatment,the disease recurrence rate is higher than those with low activity and activity. Therefore,in clinical treatment,we need to prolong the treatment course of highly active patients.更多还原