【摘要】 目的:观察四倍体黄芩D20急性毒性及亚急性毒性,并与二倍体黄芩进行比较,为其临床应用提供初步安全性评价。方法:采用改良寇氏法测定黄芩对小鼠的半数致死量(LD₅₀),若毒性较低,则测定小鼠对黄芩的最大耐受量（MTD）。结果:通过急性毒性预实验未能测出四倍体黄芩水提液LD₅₀,而小鼠对其最大耐受量为120 g/kg,相当于临床成人用量的1 200倍。大鼠亚急性毒性试验血液生化指标及其他各项指标未见异常,无明显病理变化。结论:四倍体黄芩同二倍体黄芩相似,均具有较好的安全性,临床用药安全可靠。更多还原

【Abstract】 Objective:To observe the acute toxicity to mice and sub-acute toxicity to rats of tetraploid and diploid Scutellariae Radix, so as to provide preliminary safety basis for clinical medication. Methods:According to the modified Karber’s method, the LD₅₀ of tetraploid and diploid Scutellariae Radix water extraction liquid on adult mice was determined. If the toxicity was low, it was changed to determine the maximum tolerance（MTD）. In addition, 30-day feeding experiment in rats was carried out for observing sub-acute toxicity of tetraploid and diploid Scutellariae Radix. Results: The preliminary experiment of acute toxicity was failed to detect LD₅₀. The maximum tolerance of tetraploid and diploid Scutellariae Radix to adult mice was 120 g/kg, equivalent to1 200 times of clinical dosage to adult. 30-day feeding experiment showed that blood biochemical indicators were all in the normal value range and the histopathological changes were not observed. Conclusion: Tetraploid and diploid Scutellariae Radix are relatively safe.更多还原