【摘要】 目的评估左氧氟沙星联合抗结核化疗方案治疗复治涂阳肺结核(TB)的疗效及不良反应情况。方法 67例复治涂阳TB患者的临床资料,根据治疗方案的不同将其分为对照组(30例)和研究组(37例)。对照组单纯行抗结核化疗,研究组联合左氧氟沙星治疗,比较两组病灶吸收与不良反应。结果研究组病灶吸收率81.08%高于对照组的60.00%,差异具有统计学意义(P<0.05)。研究组不良反应总发生率16.22%低于对照组23.33%,但差异无统计学意义(P>0.05)。结论复治涂阳TB患者行左氧氟沙星联合抗结核化疗方案治疗可取得良好效果,且安全性高,具临床应用价值。更多还原

【Abstract】 Objective To evaluate curative effect and adverse reactions of levofloxacin combined with anti-tuberculosis chemotherapy regimens in the treatment of retreated smear positive pulmonary tuberculosis(TB). Methods A total of 67 retreated smear positive TB patients were divided by different treatment regimens into control group(30 cases) and research group(37 cases). The control group received only anti-tuberculosis chemotherapy, and the research group received levofloxacin combined with anti-tuberculosis chemotherapy. Comparison were made on lesions absorption rate and adverse reactions. Results The research group had higher lesions absorption rate as 81.08% than 60.00% in the control group, and the difference had statistical significance(P<0.05). The research group had lower total incidence of adverse reactions as 16.22% than 23.33% in the control group, but the difference had no statistical significance(P>0.05). Conclusion Implement of levofloxacin and anti-tuberculosis chemotherapy regimens shows perfect curative effect in the treatment of retreated smear positive TB patients with high security. This method also contains application value in clinic.更多还原