【摘要】 目的:检测支气管哮喘患者外周血中肥大细胞羧肽酶的含量,研究其与哮喘患者FEV 1(%)、IgE的关系,探讨其在支气管哮喘发病机制中的作用。方法:35例临床确诊为中重度持续性支气管哮喘患者作为病例组,均行肺功能及IgE水平检测,依据血清IgE水平将支气管哮喘患者分为IgE升高组(n=20)和IgE正常(n=15)。另外,选取22名健康者作为对照组,采用ELISA法检测受试者血清肥大细胞羧肽酶水平。比较支气管哮喘患者与健康者血清中肥大细胞羧肽酶水平;分析血清肥大细胞羧肽酶水平与IgE及肺功能的相关性。结果:IgE升高组患者血清肥大细胞羧肽酶水平明显高于IgE正常组(P<0.05);支气管哮喘急性发作期患者血清肥大细胞羧肽酶水平明显高于健康对照组(P<0.05);另外,哮喘急性发作期患者血清肥大细胞羧肽酶水平与患者FEV(%)呈明显的负相关;缓解期血清肥大细胞羧肽酶水平与FEV1(%)无相关性(r=-0.421,P=0.012;r=-0.284,P=0.099)。结论:血清肥大细胞羧肽酶可能参与了支气管哮喘急性发作的气道炎症反应。更多还原

【Abstract】 Objective:To investigate the role of the mast cell carboxypetidase in the pathogenesis of bronchial asthma through measuring the serum.The mast cell carboxypetidase levels of asthma patients,and further study the relationship between the mast cell carboxypetidase levels and pulmonary function or IgE.Methods:There were person with Moderate and severe persistent asthma were recruited into this study as the case group.The experience of the pulmonary function and immunoglobulin E levels have been complicated.The person were divided into IgE increased group(n=20) and IgE normal group(n=15) according to the IgE level.And there were healthy person were recruited as the matched group.The mast cell carboxypetidase were measured using ELISA.The level of mast cell carboxypetidase were compared among asthma patients and healthy patients.The correlation between the mast cell carboxypetidase and IgE or the lung function.Results:The level of plasma mast cell carboxypetidase in the person with asthma was higher than that in healthy control group(P<0.05).The level of plasma mast cell carboxypetidase of the person in IgE increased group was higher than that in IgE normal group(P<0.05).In addition,there was a significant negative correlation between the serum mast cell carboxypetidase levels and FEV1(%) in the asthma acute phase,but there was no correlation in the stability of asthma(r=-0.42,P=0.044;r=-0.284,P=0.099).Conclusion:The mast cell carboxypetidase leve,as an inflammatory factor,could participates in the airway inflammatory response of the asthma acute phase.更多还原