【摘要】 目的探讨联合检测尿转铁蛋白(TRF)、血清胱抑素C(Cys-C)、视黄醇结合蛋白(RBP)和同型半胱氨酸(Hcy)对糖尿病肾病(DN)的早期诊断价值.方法依据糖尿病诊断标准和24 h尿白蛋白排泄率(UAER)的检查结果,将早期糖尿病肾病(DN)微量蛋白尿组患者40例(30 mg/24 h≤UAER≤300 mg/24 h)作为观察组A组,临床蛋白尿组患者40例(UAER>300 mg/24 h)作为观察组B组,同期健康体检者40例作为对照组.比较3组TRF,Cys-C,RBP和Hcy水平.结果 1)TRF,Cys-C,RBP和Hcy在A,B组中明显升高,与正常对照组比较,差异具有统计学意义(P<0.05).2)TRF,Cys-C,RBP和Hcy在B组中明显升高,与A组和对照组比较,差异具有统计学意义(P<0.05).结论 TRF,Cys-C,RBP和Hcy联合检测对于早期糖尿病肾病(DN)的诊断具有重要意义.更多还原

【Abstract】 Objective To discuss the value of combined detection of urine TRF,Serum Cystatin C,Retinol Binding Protein(RBP) and Hcy in Diagnosis of early diabetic nephropathy.Method Diagnostic criteria for diabetes and 24 h urinary albumin excretion rate(UAER) were examined.40 patients with early diabetic nephropathy(DN)(30 mg/24 h ≤ UAER ≤300 mg/24 h) as group A,40 patients with clinical albuminuria group(UAER>300 mg/24 h) as group B,physical examination is 40 cases as normal control group.The urinary TRF,Cys-C,RBP and Hcy level of three groups were compared.Results 1) Urinary TRF,Cys-C,RBP and Hcy level in the early DN group and the clinical DN group increased significantly,compared with normal control group.The difference was statistically significant(P<0.05).2) Urinary transferrin Cys-C,serum retinol binding protein and homocysteine in group B increased significantly,compared with group A and the control group,the difference was statistically significant(P < 0.05).Conclusion Urinary TRF,Cys-C,RBP and Hcy combined detection for the diagnosis of early diabetic nephropathy(DN) has important significance.更多还原