【摘要】 目前,肥胖和骨质疏松症的相关性尚未完全统一:往日研究表明,肥胖可促进骨形成,预防骨质疏松症,并降低骨折风险;近年来研究发现,超重、肥胖和低体质量都可成为骨质疏松及骨质疏松性骨折的危险因素。也就是说,肥胖或超重既可能是骨质疏松症的保护因素,也可能是其危险因素。肥胖对骨代谢存在多种影响机制,包括:体质量对骨的机械负荷刺激,脂肪含量与肌肉含量对骨形成的影响,脂肪细胞在起源上对成骨细胞的影响,脂肪细胞产生的多种激素及细胞因子对骨重建的影响等。本文叙述肥胖对骨代谢的多重影响机制,指导临床实施个体化预防和治疗方案。更多还原

【Abstract】 The correlation between obesity and osteoporosis has not yet been fully unified: past studies suggest that obesity can promote bone formation, prevent osteoporosis, and reduce the risk of fractures. In recent years, studies have found that overweight or obesity and low weight are the risk factors for osteoporosis and osteoporotic fracture. That is to say, obesity or overweight may be the protective factors of osteoporosis, and it may also be a risk factor for osteoporosis. There are many influence mechanism of obesity on bone metabolism, such as weight of mechanical loading stimulus to bone, the influence of lean mass and fat mass on bone formation, the influence of adipocytes to osteoblasts on origin, the influence of various hormones and cytokines produced by adipocytes on bone remodeling, etc. The aim of this paper is to describe the multiple effects mechanism of obesity on bone metabolism in order to implement the individualized prevention and treatment program.更多还原