【摘要】 目的探究慢性牙周炎与脑卒中之间的病因学联系。方法电子检索CBM数据库(1978—2016年)、维普、CNKI、Medline(OVID,1950—2016年)和荷兰医学文摘(EMBASE,1984—2016年)、Cochrane图书馆临床随机对照试验库(CENTRAL,2016年第9期)等中英文期刊数据库并手检中文口腔期刊,收集有关慢性牙周炎与脑卒中相关性的文献。两位研究者独立进行文献筛选、质量评价和数据提取(牙周炎患病率、临床附着丧失量、菌斑指数和血清C反应蛋白)并用Revman5.3.3软件进行Meta分析。结果最终纳入12篇文献(2篇中文、10篇英文),纳入研究对象2835例,其中脑卒中患者1396例。Meta分析结果显示,脑卒中患者牙周炎患病率明显高于对照组[OR=2.89,95%CI=(2.00,4.17),P<0.001],脑卒中患者的牙周炎较对照组更为严重[OR=1.25,95%CI=(0.50,2.00),P=0.001]且其口腔卫生更差[OR=0.32,95%CI=(0.11,0.54),P=0.004],脑卒中患者血清炎症因子C反应蛋白水平明显升高[OR=5.38,95%CI=(4.78,5.97),P<0.001]。结论慢性牙周炎与脑卒中之间可能存在一定的相关性。更多还原

【Abstract】 Objective To evaluate the etiology relationship between chronic periodontitis and stroke. Methods Electronic search was conducted to find out the association between chronic periodontitis and stroke in CBM(1978—2016),VIP chinese database,CNKI,Medline(OVID,1950—2016),EMBASE(1984—2016)and CENTRAL(2016,Issue 9). Hand search was applied to the Chinese journals in oral research. Two investigators performed reference screening, quality evaluation and data collection(including incidence of periodontitis,CAL,PI and levels of CRP). Revman 5.3.3 was applied for Meta-analysis of the data. Results Twelve referen met the inclusion criteria(2 Chinese researches and10 English researches),including 2835 participants,1396 of them with stroke. The result of Meta-analysis showed that the patients with stroke were more likely with chronic periodontitis[OR = 2.89,95%CI =(2.00,4.17),P<0.001],more severe periodontitis[OR = 1.25,95% CI =(0.50,2.00),P = 0.001]and poorer oral hygiene[OR = 0.32,95% CI =(0.11,0.54),P = 0.004]. The levels of CRP increased obviously[OR = 5.38,95% CI =(4.78,5.97),P<0.001]. Conclusion Chronic periodontitis and stroke have a possible correlation.更多还原