【摘要】 活性氧(ROS)是需氧细胞在代谢过程中产生的一系列活性氧簇,有极强的氧化作用。肺是失血性休克后最易受损伤的器官;扣押于肺组织的中性粒细胞、肺微血管内皮细胞、肺泡巨噬细胞产生大量的ROS,引起氧化应激反应,扩大炎症反应,增加细胞凋亡,损伤血管通透性,导致急性肺损伤(ALI)。本文综述ROS在失血性休克引起ALI的作用与机制,为针对ROS防治失血性休克引起的ALI提供新的思路。更多还原

【Abstract】 Reactive oxygen species(ROS) plays strong oxidation,which is produced during aerobic cells metabolism.Lung is an early damaged organ following hemorrhagic shock.ROS produced from polymorphonuclear neutrophils,pulmonary microvascular endothelial cells and alveolar macrophages,causes oxidative stress reaction,expands inflammatory response,increases apoptosis,damages vascular permeability,and subsequently results in acute lung injury(ALI).The present article reviews the role and mechanism of ROS in hemorrhagic shock-induced ALI,therefore,provides a novel approach for treatment of hemorrhagic shock-induced ALI through ROS.更多还原