【摘要】 目的探讨阿司匹林-g-壳聚糖衍生物的合成方法。方法将一定量的阿司匹林和壳聚糖加入适量三氯甲烷中,在DCC和DMAP的催化下,于50℃下反应6 h,然后通过柱层析和薄层层析制备分离,得到产物。再运用薄层层析、红外光谱、紫外光谱等检测手段进行表征。结果经过薄层层析、红外光谱、紫外光谱等分析,所得到的产物为单一成分,并且可以确定为阿司匹林-g-壳聚糖酰胺衍生物。结论在一定的催化条件下,以阿司匹林和壳聚糖为原料,经过适当的分离纯化方法,可以初步得到阿司匹林-g-壳聚糖衍生物。更多还原

【Abstract】 Objective To study the synthesis method of aspirin-g-chitosan derivatives. Methods Under the catalysis of DCC and DMAP, certain amount of aspirin and chitosan were added into the amount of chloroform, reactiing 6 h at 50℃. The products were separated by column chromatography and preparative TLC. Then, TLC, IR, UV were used to characterize the product. Results After analysis of TLC, IR and UV, the obtained product is a single component, and it can be identified as aspirin-g-chitosan amide derivatives. Conclusion Under the condition of appropriate catalyst, taking aspirin and chitosan as raw materials, aspirin-g-chitosan derivatives can be synthesized preliminary by appropriate separation and purification methods.更多还原