【摘要】 目的探讨匹多莫德对小儿肺炎支原体肺炎（MPP）的治疗效果及其对患儿免疫功能和炎性因子的影响。方法将114例MPP患儿随机分为观察组57例与对照组57例,对照组给予阿奇霉素治疗,观察组在对照组基础上加用匹多莫德治疗,对比两组患儿临床有效率、免疫功能指标及有关炎性因子水平。结果观察组有效率为93.0%,显著高于对照组的73.7%,差异有统计学意义（P<0.01）;治疗前两组患儿CD₄⁺、CD₈⁺、CD₄⁺/CD₈⁺比较,差异均无统计学意义（均P>0.05）,治疗后观察组CD₄⁺、CD₄⁺/CD₈⁺显著增高,CD₈⁺显著降低,差异均有统计学意义（均P<0.01）,对照组CD₄⁺、CD₄⁺/CD₈⁺显著增高,差异均有统计学意义（均P<0.01）,CD₈⁺无明显变化,差异无统计学意义（P>0.05）,且治疗后观察组CD₄⁺、CD₄⁺/CD₈⁺显著高于对照组,CD₈⁺显著低于对照组,差异均有统计学意义（均P<0.01）;治疗前两组患儿有关炎性因子白细胞介素-4（IL-4）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）比较,差异均无统计学意义（均P>0.05）,治疗后观察组IL-4、IL-6、IL-10水平均显著降低,差异均有统计学意义（均P<0.01）,对照组IL-4、IL-6水平显著降低,差异均有统计学意义（均P<0.01）,IL-10水平无明显变化,差异无统计学意义（P>0.05）,且治疗后观察组IL-4、IL-6、IL-10水平均显著低于对照组,差异均有统计学意义（均P<0.01）。结论匹多莫德用于小儿MPP的治疗,疗效确切,能够有效提高患儿免疫功能,降低炎症反应,利于病情恢复。更多还原

【Abstract】 Objective To explore the curative effect of pidotimod in treatment of Mycoplasma pneumoniae pneumonia（ MPP） in children and the influence on immune function and inflammatory factors. Methods A total of 114 children with MPP were randomly divided into observation group and control group,57 children in each group. The patients in control group were treated with azithromycin,while the patients in observation group were treated with pidotimod and azithromycin. The clinical effective rates,immune function indicators,and inflammatory factors were compared between the two groups. Results The effective rate in observation group was 93. 0%,which was statistically significantly higher than that in control group（ 73. 7%）（ P<0. 01）; there was no statistically significant difference in CD₄⁺and CD₈⁺levels,CD₄⁺/CD₈⁺ratio between the two groups before treatment（ all P>0. 05）; CD₄⁺level and CD₄⁺/CD₈⁺ratio significantly increased and CD₈⁺level significantly reduced in observation group after treatment,there were statistically significant differences（ all P<0. 01）; CD₄⁺level and CD₄⁺/CD₈⁺ratio significantly increased in control group after treatment（ all P<0. 01）,CD₈⁺level in control group didn’t change significantly（ P>0. 05）; after treatment,CD₄⁺level and CD₄⁺/CD₈⁺ratio in observation group were statistically significantly lower than those in control group（ all P<0. 01）; before treatment,there was no statistically significant difference in IL-4,IL-6,IL-10 levels between the two groups（ all P>0. 05）; after treatment,IL-4,IL-6,and IL-10 levels in observation group decreased significantly（ all P<0. 01）,IL-4 and IL-6 levels in control group decreased significantly（ all P<0. 01）,IL-10 level didn’t change significantly（ P> 0. 05）; IL-4,IL-6,and IL-10 levels in observation group after treatment were statistically significantly lower than those in control group（ P < 0. 01）.Conclusion The curative effect of pidotimod is exact in treatment of MPP children,it can effectively improve immune function and reduce inflammatory response,the drug is conducive to recovery of the disease.更多还原