【摘要】 目的探讨CEA、NSE、CA125、CYFRA21-1在肺癌中的检测及意义。方法回顾性分析2015年10月—2016年12月医院收治的肺部疾病患者166例,其中89例肺癌患者设为肺癌组,其余77例肺部良性病变患者设为肺部良性病变组。另选择35名健康志愿者作为健康对照组,电化学发光法检测3组血清中CEA、NSE、CA125、CYFRA21-1含量,分析单项及联合检测对肺癌的诊断价值。结果肺癌组患者血清CEA、NSE、CA125、CYFRA21-1分别为(4.32±0.83)ng/mL、(11.54±4.17)ng/mL、(37.89±6.69)U/mL、(4.02±0.56)ng/mL,均高于肺部良性病变组和健康对照组,差异有统计学意义(P<0.05)。肺部良性病变组和健康对照组血清CEA、NSE、CA125、CYFRA21-1比较差异无统计学意义(P>0.05)。CEA、NSE、CA125、CYFRA21-1单项诊断肺癌的敏感性偏低,特异度较高;而四项联合检测诊断肺癌的敏感性显著升高,为87.64%,差异有统计学意义(P<0.05);特异度略有降低,差异无统计学意义(P>0.05)。结论肺癌患者血清中CEA、NSE、CA125、CYFRA21-1升高,四项联合检测可以提高对肺癌的诊断准确性。更多还原

【Abstract】 Objective To study the test and significance of CEA, NSE, CA125, CYFRA21-1 in lung cancer. Methods166 cases of patients with lung diseases admitted and treated in our hospital from October 2015 to December 2016 were selected and divided into the lung cancer group with 89 cases and lung benign lesion group with 77 cases in each,and 35 cases of healthy volunteers were selected as the control group, and the contents of CEA,NSE,CA125,CYFRA21-1 in serum of the three groups were tested by the electrochemiluminescence, and the diagnosis value of single and combined test for lung cancer was analyzed. Results The serum CEA,NSE,CA125,CYFRA21-1 in the lung cancer group were respectively(4.32 ±0.83)ng/m L,(11.54 ±4.17)ng/m L,(37.89 ±6.69)U/m L,(4.02 ±0.56)ng/m L, which were higher than those in the lung benign lesion group and healthy control group, and the differences were statistically significant(P<0.05), and the differences in the CEA,NSE,CA125,CYFRA21-1 in serum between the lung benign lesion group and healthy control group were not statistically significant(P >0.05), and the sensitivity of single diagnosis of CEA,NSE,CA125,CYFRA21-1 for lung cancer was lower and the specificity was higher, but the sensitivity of four combined test in diagnosis of lung cancer obviously increased,(87.64%), and the difference was statistically significant(P<0.05), the specificity slightly decreased, and the difference was not statistically significant(P>0.05). Conclusion The CEA, NSE,CA125, CYFRA21-1 in serum of patients with lung cancer increase, and the four combined test can improve the diagnostic accuracy of lung cancer.更多还原