【摘要】 【目的】探讨吉西他滨联合替吉奥治疗晚期胰腺癌的疗效和安全性。【方法】选择2011年5月1日至2015年5月1日收治的87例晚期胰腺癌患者,随机分为单药组和联合治疗组,单药组采用吉西他滨单药1 000 mg/m2,第1天、第8天静脉滴注0.5 h,3周为1个疗程;联合治疗组在此基础上第1天~第14天口服替吉奥胶囊,2次/d,体表面积<1.25 m2,80 mg/d,1.25 m2≤体表面积≤1.5 m2,100 mg/d,体表面积>1.5 m2,120 mg/d。比较两组患者疗效与不良反应发生情况,记录无进展生存时间与总生存时间,并绘制生存曲线。【结果】单药组、联合治疗组患者的客观有效率分别为30.95%、35.56%,两组比较差异无统计学意义(P>0.05);疾病控制率分别为69.05%、91.11%,两组比较差异有统计学意义(P<0.05);中位无进展生存时间分别为4.4、5.5个月,差异有统计学意义(P<0.05);中位总生存时间分别为8.0、8.5个月,差异无统计学意义(P>0.05)。联合治疗组的I~II级外周神经毒性与III~IV级白细胞减少两种不良反应发生率低于单药组,差异有统计学意义(P<0.05)。【结论】吉西他滨联合替吉奥治疗晚期胰腺癌疗效显著,不良反应轻,安全性较高。更多还原

【Abstract】 【Objective】To disscuss the safety and efficacy of gemcitabine combined with S-1 in the treatment of advanced pancreatic cancer.【Methods】Eighty-seven patients with advanced pancreatic cancer were allocated into the control group and the observation group randomly from May, 2011 to May, 2015. Both groups received gemcitabine single-agent 1 000 mg/m2 through intravenous drip in day 1 and 8 and 21 days as a treatment cycle of chemotherapy. The observation group received S-1 80/100/120 mg/d twice a day for the first 14 days. Efficacy, adverse reactions, progression-free survival(PFS) and overall survival(OS) in 2 groups were analysed and survival curves were drawn.【Results】Objective response rate(RR) of the control group and the observation group were 30.95% and 35.56%,respectively, with no statistical significance(P>0.05). Disease control rate(DCR) of the control group and the observation group were69.05% and 91.11%,respectively, with statistical significance(P<0.05). PFS of the control group and the observation group were 4.4and 5.5 months,respectively, with statistical significance(P<0.05). OS of the control group and the observation group were 8.0 and 8.5months,respectively, with statistical significance(P>0.05). Incidence rate of peripheral neurotoxicity of Grade I~II and leukopenia of Grade III~IV in the observation group were lower than that in the observation group(P<0.05).【Conclusion】Gemcitabine combined with S-1 in the treatment of advanced pancreatic cancer is effective, less adverse reactions and safety.更多还原