【摘要】 目的探讨生化检测指标对糖尿病肾病(DN)早期诊断的临床价值。方法选取108例糖尿病(DM)患者,根据其尿蛋白排泄率将其分为单纯DM组(n=35)、早期DN组(n=33)和DN组(n=40),对比生化检测指标差异。结果相较于单纯DM组,早期DN组和DN组的Cys C、RBP、β2-MG、m ALB以及TRF水平均明显升高,组间对比,差异具有统计学意义(P<0.05);DN组的Cys C、RBP、β2-MG、m ALB以及TRF水平均高于早期DN组,组间对比,差异具有统计学意义(P<0.05)。结论 DN患者Cys C、RBP、β2-MG、m ALB以及TRF水平均于早期显著升高,可将其用于疾病早期诊断和监测中。更多还原

【Abstract】 Objective To explore the clinical value of biochemical detection index in the early diagnosis of DN. Methods 108 patients with diabetes mellitus(DM) were divided into DM group(n =35), early DN group(n =33) and DN group(n =40) according to the excretion rate of urinary protein, the biochemical test indicators were comparied. Results Compared with group DM, early DN group and DN group Cys C, RBP, β2-MG, m ALB and TRF levels were significantly increased, there was significant difference between two groups(P < 0.05). DN group of Cys C, RBP, β2-MG, m ALB and beta TRF levels were significantly higher than that in the early DN group, there was statistically significant difference between two groups(P< 0.05). Conclusion The levels of Cys C, RBP, β2-MG, m ALB and TRF in DN patients were significantly higher than those in early stage, and it could be used in the early diagnosis and monitoring of disease.更多还原