【摘要】 目的:探讨2型糖尿病（T2DM）并发脑梗死患者血浆同型半胱氨酸（Hcy）水平与颈动脉硬化水平的关系。方法:将2型糖尿病患者89例按是否合并脑梗死分为T2DM合并脑梗死组（45例）和单纯T₂DM组（44例）,另选择来我院体检的健康人群30例作为对照组,对所有人群测量收缩压（SBP）,舒张压（DBP）,体重指数（BMI）并进行Hcy、空腹血糖（FBG）、糖化血红蛋白（HbA1C）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）、颈动脉内-中膜厚度（IMT）等相关指标检测,分析同型半胱氨酸与IMT的相关性。结果:（1）T₂DM合并脑梗死组Hcy水平明显高于单纯T₂DM组和对照组,单纯T₂DM组Hcy水平高于对照组（P<0.01）;（2）T₂DM并发脑梗死组TG水平明显高于单纯T₂DM组和正常对照组（P<0.01）;（3）T2DM并发脑梗死组和单纯T₂DM组颈动脉超声均显示有不同程度硬化表现,但T₂DM并发脑梗死组的IMT、斑块检出率均高于单纯T₂DM组（P<0.05）和正常对照组（P<0.01）。相关性分析显示:Hcy是颈动脉硬化的危险因素。Hcy与IMT、HbA1C均呈正相关（P<0.05）。结论:高Hcy是T₂DM患者脑梗死的危险因素。更多还原

【Abstract】 Objective:To explore correlation between homocysteine（Hcy）and carotid atherosclerosis in type 2diabetes mellitus（T2DM）patients with cerebral infarction.Methods:89patients with type 2diabetes were randomly divided into two groups（45with cerebral infarction and 44 without any complication）.And 30 healthy individuals as control group.All the subjects were detected the serum level of homocysteine,laboratory data,intima-media thickness（IMT）and the incidence and degree of carotid atherosclerosis.Results:（1）The serum level of homocysteine in T₂DM patients with cerebral infarction was significantly higher than those in T₂ DM only（P<0.05）and control group（P<0.01）.（2）The TG level in T₂DM patients with cerebral infarction was significantly higher than those in T₂ DM only and control group（P<0.01）.（3）The incidence、degree of carotid atherosclerosis and IMT in T₂DM patients with cerebral infarction were significantly higher than those in T₂DM only（P<0.05）and control group（P<0.01）.（4）There was a relationship between the serum level of Hcy and the degree of carotid artery atherosclerosis in T₂DM patients（P<0.05）.Conclusion:The serum level of Hcy and carotid artery atherosclerosis are both risk factors for cerebral infarction of T₂DM patients.更多还原