【摘要】 巯基嘌呤甲基转移酶(thiopurine s-methyltransferase,TPMT)是硫嘌呤类药物在体内代谢的关键酶,其活性的高低可直接影响该类药物的临床疗效和毒性程度。鉴于此,该文主要从"用药前是否需要检测TPMT活性、是检测基因型还是检测表型以及TPMT基因型检测方法的选择"三个比较受关注的方面作一综述,旨在提高对TPMT遗传多态性在硫嘌呤类药物个体化治疗中的意义的认识。更多还原

【Abstract】 Thiopurine S-methyltransferase(TPMT) is an important and key cytoplasmic enzyme in the metabolism of thiopurine drugs,whose activity can directly determine the amount of thiopurine drugs metabolized to cytotoxic 6-thioguanine nucleotides and consequently influence clinical efficacy and adverse drug reactions of thiopurine drugs. In order to deepen knowledge and role of genetic polymorphism of tpmt in the individualized thiopurine drug treatment,this present review mainly covered the following three frequently concerned aspects, including i) whether or not to determine the activity of TPMT priot to treatment of thiopurine drugs;ii) to genotype or to phenotype;iii) how to choose genotype methods.更多还原