【摘要】 大肠癌包括结肠癌和直肠癌,是全球常见的消化道恶性肿瘤,其发病率在逐年增加。MicroRNA(miRNA)是一类长度约18~24个核苷酸的非编码小分子RNA,能够调控基因的表达,参与调节细胞的生长增殖、分化、凋亡等多种关键细胞过程,与大肠癌的发生发展密切相关。同时近些年研究报道提示,miRNA广泛参与到中药抗肿瘤的作用过程中,在miRNA水平探究中医药防治大肠癌的分子机制具有重要意义,为现代中医药理论的发展提供了新的突破点。更多还原

【Abstract】 Colorectal cancer,including colon and rectal cancer,is a common malignant tumor of the digestive tract,the incidence increased year by year.MicroRNAs(miRNAs) are small non-coding RNAs of about 18-24 nucleotides in length.They regulate the expression of genes and participate in the regulation of cell growth,differentiation and apoptosis.Occurrence and development are closely related.At the same time in recent years research reports suggest that miRNAs are widely involved in the anti-tumor effect of traditional Chinese medicine process.It is of great significance to explore the molecular mechanism of traditional Chinese medicine in the prevention and treatment of colorectal cancer at the level of miRNA,which provides a new breakthrough for the development of modern TCM theory.更多还原