【摘要】 目的苯丙胺类兴奋剂所致精神障碍者的临床变化追踪观察。方法采用PANSS量表、HAMD抑郁量表、YMRS躁狂量表及自编的一般情况量表,对在我院首次住院的420例苯丙胺类兴奋剂所致精神障碍的患者和他们中再次入院80例患者为调查对象进行问卷调查。结果苯丙胺滥用者以青少年居多,男性多于女性,文化素质普遍偏低,职业以无业和个体为主,平均吸毒时间为4.67年。首次入院组与再次入院组在精神疾病家族史、药物滥用时间上差异有统计学意义(P<0.05);首次入院与再入院时PANSS评分、HAMD评分、YMRS评分差异无统计学意义(P>0.05);再次入院维持苯丙胺类所致精神障碍诊断为62例(77.5%)、精神分裂症为11例(13.8%)、双相情感障碍躁狂发作为4例(5%)、抑郁障碍为3例(3.7%)。结论苯丙胺类兴奋剂可直接引起精神障碍,可能为其他精神疾病的伴发症状、或为其他精神疾病的诱发原因。更多还原

【Abstract】 Objective Follow-up observation of clinical changes in patients with mental disorders induced by amphetamines.Methods Positive and Negative Syndrome Scale(PANSS),HAMD depression scale,Young Mania Rating Scale(YMRS)and self-made general condition scale were adopted to conduct a questionnaire survey on 420 cases of mental disorder induced by amphetamines who were hospitalized for the first time in our hospital and 80 cases among them who were rehospitalized later.ResultsMost Amphetamine abusers were youngsters,more male than female,generally with low cultural quality,who were mostly unemployed or individuals and their average drug time was 4.67 years.There were statistically significant difference in Family history of mental disorders and drug abuse time between first-time-hospitalization group and rehospitalization group(P<0.05).As for rehospitalized patients,the difference of PANSS score,HAMD score and YMRS score between the first hospitalization and rehospitalization were not statistically significant(P>0.05).As for readmission diagnosis,62 cases maintained mental disorder induced by amphetamines(77.5%),11 cases diagnosed schizophrenia(13.8%),4cases diagnosed maniacalis insultus of bipolar affective disorder(5%)and 3cases diagnosed depressive disorder(3.7%).Conclusion Amphetamine type stimulants can directly cause mental disorders and may be concomitant symptoms of other psychiatric disorders or induce cause of other psychiatric disorders.更多还原