【摘要】 目的通过Meta分析胃癌患者幽门螺杆菌感染情况与其预后的关系。方法检索1990-2016年间Pub Med、Cochrane、CNKI数据库中涉及幽门螺杆菌与胃癌预后的研究,以风险比(HR)和95%置信区间(95%CI)为合并指标分析幽门螺杆菌感染胃癌患者与幽门螺杆菌阴性胃癌患者之间总体生存率(OS)、无瘤生存率(DFS)的差异,并通过亚组分析了解可能的原因。结果共纳入符合条件的研究19篇,总共包括4 097例患者。结果显示幽门螺杆菌阳性胃癌患者的OS比阴性患者好(HR:0.71,95%CI:0.56~0.85)。亚组分析中,亚洲地区人群OS的HR为0.76(95%CI:0.52~0.99);欧美地区人群OS的HR为0.66(95%CI:0.52~0.81)。结论幽门螺杆菌感染的胃癌患者较未感染者预后较好。更多还原

【Abstract】 Objective Helicobacter pylori(HP) is considered to be a major risk factor for the development of gastric cancer;however,the effect of Helicobacter pylori infection on prognosis of gastric cancer patient is controversial. Purpose:We performed a Meta-analysis to evaluate whether Helicobacter pylori infection is a prognostic factor for gastric cancer patient. Methods We searched Pub Med,Cochrane and CNKI databases for studies about H.pylori and gastric cancer which were published from 1990 to 2016. We used hazard ratio(HR)and its 95% confidence interval(95%CI)to assess the strength of association. Results A total of 19 studies containing 4 097 patients were included in this analysis. The pooled HR was 0.71(95%CI:0.56~0.85)for overall survival(OS)and 0.80(95%CI:0.48~1.12)for disease free survival(DFS).We observed a protective role of Helicobacter pylori in different subgroups stratified by ethnicity and found that gastric cancer patients with Helicobacter pylori infection had better overall survival compared to those without Helicobacter pylori infection.Conclusion GC patients with Helicobacter pylori infection have better overall survival rate compared to those without Helicobacter pylori infection.更多还原