【摘要】 目的观察耐多药结核患者对氧氟沙星(Ofx)、丁胺卡那霉素(Am)二线抗结核药物的敏感性,为临床治疗和防治提供理论依据。方法选取2014年3月—2015年9月兰州市肺科医院接诊的90例耐多药结核病患者进行研究。采用硝基苯甲酸法进行菌株鉴定,应用比例法进行药敏试验,分析耐药情况。结果 90例耐多药患者中,对Ofx和Am的耐药率分别为27.78%和12.22%,Ofx的耐药率明显高于Am,其差异有统计学意义(P<0.05)。同时耐Ofx和Am的患者3例,占3.33%。不同类型、不同性别以及不同年龄组的耐多药结核患者对Ofx和Am的耐药率差异无统计学意义(P>0.05)。但初治和复治患者、男性、中年组患者对Ofx和Am耐药率相对较高。结论临床实践中应规范使用Ofx和Am,避免结核病患者产生广泛耐药。更多还原

【Abstract】 Objective To observe the sensitivity of multi-drug resistant tuberculosis patients to ofloxacin(Ofx) and amikacin(Am),and we provide theoretical basis for clinical treatment and prevention. Methods A total of 90 cases of MDRTB patients detected in Lanzhou Pulmonary Hospital from March 2014 to September 2015 were researched. The strain was identified by using the method of nitrobenzene,and the drug sensitivity test was carried out by using the ratio method. Results In 90 MDR-TB patients,the resistance rates of Ofx and Am drugs were 27.78% and 12.22% respectively. The former was significantly higher than the latter(P<0.05). Besides,there were 3 cases accounting for 3.33% who were resistant to Ofx and Am at the same time. It also showed that there was no significant difference in resistance to Ofx and Am between different registration classifications,genders and age groups(P>0.05). Conclusion It is essential that Ofx and Am are used properly in clinical practice,only in this way,the extensive drug-resistance may be avoided.更多还原