【摘要】 目的 探讨艾司西酞普兰联合小剂量奥氮平治疗强迫症的临床疗效和安全性。方法将60例强迫症患者随机分为两组,各30例。两组均口服艾司西酞普兰治疗,研究组联合小剂量奥氮平治疗,观察8周。于治疗前和治疗第4周、第8周采用Yale-Brown强迫量表、汉密顿焦虑量表、汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应。结果 治疗各时段两组各量表评分均较治疗前显著下降(P<0.01),同期研究组较对照组下降更显著(P<0.01);治疗8周末研究组有效率86.2%,对照组为60.7%,研究组显著高于对照组(P<0.05)。两组不良反应均较轻微。结论艾司西酞普兰联合小剂量奥氮平治疗强迫症具有增效作用,疗效显著、起效快、安全性高、依从性好,优于单用艾司西酞普兰治疗。更多还原

【Abstract】 Objective To explore the efficacy and safety of escitaloperam combined with small-dose olanzapine in the treatment of obsessive-compulsive disorder（OCD）.Methods Sixty OCD patients were randomly divided into two groups of 30 ones each.Both groups took orally escitaloperam and research group was plus small-dose olanzapine for 8 weeks.Efficacies were assessed with the Yale-Brown Obsessive-compulsive Scale（Y-BOCS）,Hamilton Anxiety Scale（HAMA） and Hamihon Depression Scale（HAMD） and adverse reactions with the Treatment Emergent Symptom Scale（TESS） before treatment and at the ends of the 4^th and 8^th week of treatment.Results All scales scores of both groups at all time periods lowered more significantly after treatment compared withpre-treatment（P<0.01）,so did those in research than control group（P<0.01）;effective rate was respectively 86.2%in research and 60.7%in control group and the former significantly higher than the latter at the end of the 8^th week（P<0.05）.Adverse reactions of both groups were mild.Conclusion Escitaloperam combined with small-dose olanzapine has a synergism and an evident effect in the treatment of OCD,takes effect more rapidly,and has higher safety and better compliance compared with single escitaloperam.更多还原