【摘要】 目的探讨侵袭性赛多孢霉属感染的临床表现和实验室检查特点。方法收集2011年1月至2017年4月收治的8例赛多孢霉属患者的临床资料,对赛多孢霉属感染相关病例的临床表现、诱发因素和实验室检查的特点进行回顾性分析。结果8例患者中检出尖端赛多孢霉6株,波氏赛多孢霉1株,多育赛多孢霉1株。外伤、环境暴露和免疫力降低是赛多孢霉属感染的常见诱发因素。标本直接镜检均查见有隔菌丝,阳性率100%。菌落生长速度相对较快,侵袭力强,菌落形态多样,呈白色羊绒状至黑酵母样,随着培养时间的延长,从菌落中心开始颜色逐渐变深,结合镜下形态可进行菌属的快速鉴别。结论侵袭性赛多孢霉属感染病程进展迅速,病情凶险,以尖端赛多孢霉感染最多见。应加强对赛多孢霉属感染疾病的认识,提高诊治水平。更多还原

【Abstract】 Objective To investigate the clinical manifestation and the characteristics of laboratory examinations of invasive Scedocporium infection. Methods The clinical data of 8 patients infected with Scedosporium from January 2011 to April 2017 were collected and retrospective analysis combined with related literatures was performed. Results Among the 8 patients,6 strains of S. apiospermum,1 strains of Peudallescheria boydii and 1 strains of S. prolificans were detectable. The predisposing factors of Scedosporium infection were trauma,environmental exposure and hypoimmunity. The septahypha in specimens could be directly observed under microscopic examination with positive rate 100%. The growth speed of cultured colony was relatively fast and the invasiveness was strong.The colony of Scedosporium displayed various forms from white cashmere to black yeast sample. The color was gradually become dark from the center of colony with lengthening time of cultivation. Scedosporium could be identified by microscopic morphology combining culture technique. Conclusion The course of invasive Scedosporium infection may progress rapidly with serious and dangerous illness state. The most common infection of Scedosporium should be induced by S. apiospermum. The knowledge and understanding for Scedosporium infection should be strengthened to improve the level of diagnosis and treatment.更多还原