【摘要】 目的:探讨首次抑郁发作患者米那普仑治疗后负性自动思维、述情障碍及生活质量的变化。方法:对89例首次抑郁发作患者给予米那普仑治疗,分别于治疗前、治疗12周后进行负性自动思维问卷(ATQ)、多伦多述情障碍量表(TAS-20)及生活质量综合评定问卷(GQLI)评估,并进行比较及相关性分析。结果:米那普仑治疗12周后,患者ATQ评分显著低于治疗前(t=5.90,P<0.01);TAS-20中情感辩别不能因子分、情感描述不能因子分及总分较治疗前显著降低(P均<0.01);外向性思维因子分治疗前后差异无统计学意义;GQLI中的躯体健康、心理健康、社会功能维度评分及总分较治疗前显著增高(P均<0.01);物质生活条件维度评分治疗前后差异无统计学意义。治疗前ATQ评分与TAS-20中情感辩别不能、情感描述不能因子分及总分呈正相关(P均<0.01),与外向性思维因子分无相关性;治疗前ATQ评分与GQLI各维度评分及总分呈负相关(P<0.01或P<0.05)。结论:米那普仑治疗能够改善首次抑郁发作患者的负性自动思维水平,降低述情障碍的强度,提高生活质量。更多还原

【Abstract】 Objective: To explore the changes of negative automatic thoughts,alexithymia and life quality after treatment with milnacipran in first-episode depressive patients. Method: Eighty-nine first-episode depressive patients were treated with milnacipran. They were assessed with negative automatic thoughts questionnaire(ATQ),toronto alexithymia scale(TAS-20) and generic quality of life inventory(GQOLI) before and 12 weeks after treatment; the scores were compared between before and after treatment. The correlation among them were analyzed. Results: After 12-week treatment with milnacipran,ATQ score was significantly decreased than before(t = 5. 90,P < 0. 01); the total score of TAS and scores of difficulty in identifying feelings and difficulty in describing feelings were also significantly decreased than before(all P < 0. 01),but except the score of extroversion. Compared to the before treatment,the total score of GQL and factor scores of body function,mental function,social function were significantly increased(all P < 0. 01),but except the score of material life conditions. Before treatment,ATQ score was positively correlated with total score of TAS and scores of difficulty in identifying feelings and difficulty in describing feelings(all P < 0. 01),but had no correlation with score of extroversion; while it was negatively correlated with total score of GQL and each factor score(P < 0. 05 or P <0. 01). Conclusion: Milnacipran can cut negative automatic thoughts,then reduce the intensity of alexithymia and improve life quality for first-episode patients with depression.更多还原