【摘要】 目的了解江苏省涟水、阜宁两县3~11月龄婴儿b型流感嗜血杆菌荚膜多糖(Hib-PRP)自然感染抗体水平,评价地区差异。方法通过查阅预防接种证,在两县共筛选无Hib疫苗接种史3~11月龄婴儿3 061人,采集静脉血约2mL,分离血清,采用酶联免疫吸附试验检测Hib-PRP抗体,计算两县入组婴儿Hib-PRP抗体几何平均浓度(GMC)、短期保护率、长期保护率,并进行比较。结果 Hib-PRP抗体总GMC为0.18mg/L,涟水县为0.19mg/L,阜宁县为0.18mg/L,差异无统计学意义(P=0.178);阜宁县短期、长期保护率(1.64%、23.85%)均高于涟水县(0、21.56%)。阜宁县3~5月龄婴儿抗体GMC(0.28mg/L)明显高于涟水县(0.13mg/L);而6~8月龄和9~11月龄婴儿抗体GMC(0.10mg/L和0.12mg/L)明显低于涟水县(0.21mg/L和0.57mg/L),差异均有统计学意义(P值均<0.05)。随年龄增长,阜宁县短期保护率呈上升趋势,长期保护率呈先下降后上升趋势;涟水县长期保护率亦随年龄增长呈上升趋势。结论江苏省涟水、阜宁县3~11月龄婴儿Hib-PRP自然感染抗体水平存在地区差异。更多还原

【Abstract】 Objective To investigate the natural immunity antibody level to Haemophilus type b polysaccharide among infants from 3to 11 months old in Lianshui and Funing county;to compare the difference of antibody levels between different counties.Methods A total of 3 061 unvaccinated infants of 3to 11 months old from 2counties were selected by reviewing immunization cards,who were subjected to analysis of Hib-PRP antibody in serum by ELISA after 2mL blood was collected and serum was separated.The geometric mean concentration(GMC),short-term protection rate and long-term protection rate of Hib-PRP antibody of infants in 2counties were calculated and compared.Results The overall GMC of Hib-PRP antibody was0.18mg/L,the GMC was 0.19mg/L and 0.18mg/L among infants in Lianshui and Funing county,respectively,with no statistical difference(P=0.178).The short-term and long-term protection rates of Funing county(1.64%,23.85%)were higher than those of Lianshui county(0,21.56%).The GMC of infants of 3to 5months old in Funing county(0.28mg/L)was significantly higher than that of Lianshui county(0.13mg/L);while GMCs of infants of 6to 8months old and 9to 11 months old in Funing county(0.10mg/L,0.12mg/L)were significantly lower than those of Lianshui county(0.21mg/L,0.57mg/L),both with significant difference(all P<0.05).The short-term protection rate showed an ascending trend and the long-term protection rate decreased first and then increased in Funing county,while the long-term protection rate showed an ascending trend in Lianshui upon age incensement.Conclusion There was regional difference for natural antibody levels of infants of 3to 11 month old to Hib-PRP in Lainshui and Funing county in Jiangsu province.更多还原