【摘要】 组蛋白去乙酰化酶(HDAC)在生物体中广泛表达,是许多生理过程的关键酶,参与细胞的各种重要活动,包括染色质重塑、蛋白转录调节、细胞周期、衰老、氧化应激、炎症和免疫基因的表达等。研究表明,组蛋白乙酰化和去乙酰化平衡状态与呼吸道炎性相关疾病的发生发展密切相关,其表达失衡可导致炎症基因的表达及氧化应激的发生。本文从HDAC的结构分类及其与呼吸道相关炎性疾病发生发展的关系这两方面进行综述。更多还原

【Abstract】 Histone deacetylases(HDAC) are pivotal enzymes in many physiological processes widely expressed in almost all tissues including chromatin remodeling, regulation of protein transcription, cell cycle, aging, oxidative stress, inflammation and expression of immune genes. Recent studies indicated that the equilibrium state of histone acetylation and deacetylation is closely related to respiratory tract inflammation, and the unbalanced expression of HDAC could induce the expression of genes related to the inflammatory cytokines and oxidative stress. Now the structure and classification of HDAC and the updated results on HDAC in the inflammatory respiratory diseases are herewith reviewed in present paper.更多还原