【摘要】 c-kit~+细胞主要来源于骨髓和心脏,存在多种细胞亚群。目前研究表明,c-kit~+细胞是治疗心肌梗死的理想细胞,但其主要向心肌分化还是向血管内皮分化存在较大争议。因此,有必要重新认识c-kit~+细胞的分化潜能,且深入探讨发育不同阶段和局部微环境对于c-kit~+细胞分化的影响。这对于显著提高c-kit~+细胞移植修复梗死心肌的效率具有重要意义。更多还原

【Abstract】 c-kit~+ cells are mainly derived from bone marrow and cardiac tissue. The cells include various subpopulations. Recent studies have shown that c-kit~+ cells are a kind of ideal cells of transplantation therapy for myocardial infarction. However,there is a great debate on the differentiation efficiency of c-kit~+ cells towards cardiomyocytes and endothelial cells. Therefore,it is necessary to evaluate the potential of c-kit+cell differentiation and explore the effects of different developmental stages and microenvironments on differentiation of c-kit+cells again.These studies could be significant for increasing efficiency of c-kit+cell transplantation in repairing the infarcted myocardium.更多还原