【摘要】 目的研究氢吗啡酮复合氟比洛芬酯在骨科下肢术后静脉自控镇痛(patient-controlled intravenous analgesia,PCIA)中的效果。方法收集本院在腰硬联合麻醉下行骨科下肢手术的患者90例,分为三组,SF组:舒芬太尼2~3μg/kg;H组:氢吗啡酮0.12~0.14 mg/kg;KH组:氢吗啡酮0.12 mg/kg+氟比洛芬50 mg。记录术后2 h、6 h、12 h、24 h、48 h的视觉模拟评分(visual analogue scale,VAS),按压次数,恶心、呕吐、呼吸抑制及消化道出血不良反应的发生。结果三组患者均未发生呕吐、呼吸抑制及消化道出血不良反应。与SF组比较,KH和H组恶心发生例数减少(P<0.05)。按压次数KH组低于SF和H组(P<0.05)。与SF和H组比较,KH组VAS评分明显降低(P<0.05)。结论氢吗啡酮复合氟比洛芬酯用于骨科下肢PCIA效果好,不良反应少,是一种安全有效的镇痛方法。更多还原

【Abstract】 Objective To study the clinical effects of hydromorphone combined with flurbiprofen axetil for postoperative analgesia in lower extremity surgery. Methods Ninety patients undergoing lower extremity surgery combined spinal-epidural anesthesia were randomly divided into three groups: SF group(sufentanil 2 ~ 3 μg/kg); H group(hydromorphone 0. 12 ~ 0. 14 mg/kg); KH group(hydromorphone 0. 12 mg/kg + flurbiprofen axetil 50 mg). The VAS score,nausea,vomiting,respiratory depression and digestive tract bleeding were recorded at 2 h,6h,12 h,24 h and 48 h after surgery respectively. Results None of the three groups had vomiting,respiratory depression and digestive tracthemorrhage. Compared with SF group,the incidence of nausea were decreased in H and KH groups(P < 0. 05). The number of effective analgesia pump pressure in KH group were less than SF and H groups(P < 0. 05). Compared with SF and H groups,the VAS score was significantly decreased in KH group(P < 0. 05). Conclusion The effect of hydromorphone combined flurbiprofen axetil postoperative analgesia in lower extremity surgery are good,has less adverse reaction,and is a safe and effective method for postoperative analgesia.更多还原