【摘要】 目的:系统评价桂枝加厚朴杏子汤治疗咳嗽变异型哮喘的疗效和安全性。方法:计算机检索Pub Med、Cochrane Library、Embase、中国生物医学文献数据库、万方数据库、中国知网数据库、维普数据库及手工检索有关桂枝加厚朴杏子汤治疗咳嗽变异型哮喘的随机对照试验研究文献。对纳入的研究作质量评价并进行资料提取后,使用Rev Man5.3.5软件对其作Meta分析。结果:最终纳入6篇文献研究,各研究间存在统计学异质性(P=0.05,I~2=55%),选择随机效应模型汇总RR=1.24,95%可信区间为(1.11,1.40),P=0.000,2,差异有统计学意义。结论:桂枝加厚朴杏子汤治疗咳嗽变异型哮喘有一定的效果,但所纳入的研究数量有限,且文献质量较低,影响了证据的强度,需要质量更高的随机对照试验来得出更高强度的证据。更多还原

【Abstract】 Objective: To evaluate the efficacy and safety Guizhi Houpo Xingzi Decoction on cough variant asthma. Methods: Computer retrieval databases such as Pub Med, Cochrane Library, Embase, CMB database,Wanfang database, CNKI database, VIP database and manual retrieval of Guizhi Houpo Xingzi Decoction in the treatment of randomized controlled trials of cough variant asthma. After the quality evaluation and data extraction of the included literatures, the Rev Man software was used for Meta analysis. Results: A total of 6 studies were included; 6 studies showed statistical heterogeneity(P=0.05, I~2=55%), and random effect model was selected to summary, RR=1.24, 95%(CI 1.11, 1.40), P=0.000,2, with statistical difference. Conclusion: Systematic review results indicate that Guizhi Houpo Xingzi Decoction showed a certain effect on cough variant asthma. However,the limited number of studies included and the low quality of the literature affected the strength of the evidence and more high-quality randomized controlled trials are required to produce higher strength evidence.更多还原