【摘要】 目的观察丙泊酚联合右美托咪定在术中麻醉维持中的效果,探讨右美托咪定的适宜剂量。方法选取2015年1月至12月在我院进行择期手术的全麻患者100例,按照随机数表法随机分为A,B,C,D组,每组25例,应用靶控浓度为4ug/m L的丙泊酚进行诱导麻醉,气管插管后,将丙泊酚浓度改为2ug/m L,B,C,D组患者分别予持续泵入0.2ug/kg、0.4ug/kg、0.8ug/kg右美托咪定,A组泵入等量生理盐水,记录其在进入手术室后、插管后当时、插管后30 min、插管后60 min心率、血压及BIS的变化情况。结果随着右美托咪定剂量增加,镇静深度逐渐加深,差异有统计学意义(P<0.05)。右美托咪定剂量为0.8ug/kg时患者出现术中循环不稳定的风险增加(P<0.05)。B,C,D组术中知晓发生率明显降低。结论全身麻醉中,联合应用0.4ug/kg右美托咪定和2ug/m L丙泊酚进行维持,可达到维持血流动力学稳定和保证一定麻醉深度的效果。更多还原

【Abstract】 Objective To explore the effect of propofol combined dexmedetomidine in the maintenance of anesthesia and to determine the appropriate dose of dexmedetomidine.Methods 100 cases from Jan. 2015 to Dec. 2015 were divided into 4 groups randomly,25 cases in each group.All the patients were received propofol 4ug/m L as anesthesia induction.The dose of dexmedetomidine were 0,0.2ug/kg,0.4ug/kg and 0.8ug/kg in each group.The heart rate,blood pressure and BIS were recorded.Results The sedation depth were increased with the increase dose dexmedetomidine(P<0.05).When the dose was 0.8ug/kg,the risk of hemodynamic instability was increased.What’s more,the incidence of intraoperative awareness was decreased significantly in group B,C and D.Conclusion 0.4ug/kg dexmedetomidine and 2ug/m L propofol could provide well maintenance in anesthesia.更多还原