【摘要】 目的探讨汉族、维吾尔族肺结核患者血清中人肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）的含量以及民族间差异,并分析其与性别之间的关联。方法选取肺结核患者汉族132例,维吾尔族122例,用酶联免疫吸附双抗体夹心法测定患者血清中TNF-α、IL-10的含量。结果汉族和维吾尔族的肺结核患者血清中TNF-α分别为（21.72±7.18）,（29.86±8.61）pg·mL^-1;IL-10分别为（34.90±11.18）,（41.65±18.11）pg·mL^-1,差异均有统计学意义（均P<0.05）。维吾尔族肺结核患者男性与女性血清IL-10分别为（44.93±18.56）,（38.95±13.13）pg·mL^-1,差异有统计学意义（P<0.05）;而TNF-α未见性别差异。汉族肺结核患者的上述因子均未见性别差异。结论新疆汉族肺结核患者血清TNF-α、IL-10含量和维吾尔族有明显差异,IL-10血清含量在维吾尔族不同性别的肺结核患者间也有差异。更多还原

【Abstract】 Objective To investigate the levels of human tumor necrosis factor-α（TNF-α） and interleukin-10（IL-10） in the serum of Han and Uygur tuberculosis（TB） patients,and to analyze the relationship between sexes.Methods A total of 132 Han patients and 122 Uygur patients with TB were enrolled in this study.The levels of TNF-αand IL-10 in serum were measured by commercially available enzyme-linked immune-sorbent assay（ELISA）.Results The serum TNF-αof the Han and Uygur patients were（21.72 ± 7.18）,（29.86 ± 8.61）pg · mL^-1; IL-10 levels in the Han and Uygur patients were（34.90 ± 11.18） pg·mL^-1,（41.65 ± 18.11） pg·mL^-1.There were significant differences between the Han and the Uygur patients（P < 0.05）.The concentration of serum IL-10 in male and female patients were（44.93 ± 18.56）,（38.95 ± 13.13） pg·mL^-1,and significant difference was found between the two genders（P < 0.05） in Uygur,while there was no significant difference in TNF-α.Moreover,no significant difference was found in IL-10 and TNF-α between the two genders in Han patients.Conclusion There were significant differences in the serum TNF-α and IL-10 between the Han and the Uygur patients,while significant difference was also found in the serum TNF-α between the two genders in Han and Uygur TB patients.更多还原