【摘要】 目的:了解胆囊结石患者胆汁中病原菌种类及其耐药性,为患者术前和细菌培养及药敏结果回报前抗菌药物的选择提供参考。方法:选取2011年12月至2015年3月期间的1 471例胆囊结石患者胆汁标本,对从中分离的菌株及其耐药性进行回顾性分析。结果:参与统计的1 471份胆汁标本中,共有283例胆汁培养阳性,阳性率19.24%;283例阳性结果中,共培养出320株细菌。其中以革兰氏阴性菌为主,共245株,占76.56%;革兰氏阳性菌72株,占22.50%;真菌3株,占0.94%。分离量排列前6位的细菌依次为大肠埃希菌、阴沟肠杆菌、铜绿假单胞菌、肺炎克雷伯菌肺炎亚种、屎肠球菌、粪肠球菌。其中,大部分菌株对美罗培南、哌拉西林/他唑巴坦、亚胺培南、环丙沙星、阿米卡星敏感;对红霉素及一、二代头孢类药物耐药性较高。结论:来就诊的内蒙古科技大学包头医学院第一附属医院胆囊结石患者胆汁感染以革兰氏阴性菌为主,病原菌对抗菌药物已产生了一定的耐药性。更多还原

【Abstract】 Objective: To know the types of pathogenic bacteria and their drug resistance in the patients with cholecystolithiasis and to provide laboratory reference for the empirical use of antimicrobial agents before the operation and the results of bacterial culture and drug sensitivity test.Methods: 1 471 patients with cholecystolithiasis hospitalized in the First Affiliated Hospital of Baotou Medical College from December 2011 to March 2015 were chosen,with the isolated strains and their drug resistance retrospectively analyzed. Results: In 1 471 cases of bile samples from patients with cholecystolithiasis,there were 283 cases of positive bile culture,the positive rate being 19. 24 %; 320 strains of bacteria were cultured from 283 cases of positive results. Among all the strains cultured,there were 245 strains of the gram negative bacteria,accounting for 76. 56%,72 strains of gram positive bacteria,accounting for 22. 50 % and 3 strains of fungi,accounting for 0. 94 %. The separation volume ranking the top 6 of the bacteria were escherichia coli,enterobacter cloacae,pseudomonas aeruginosa. Klebsiella pneumoniae,enterococcus faecium and enterococcus faecalis. Among them,most strains were sensitive to meropenem,piperacillin/tazobactam,imipenem,ciprofloxacin and amikacin,and were highly resistant to erythromycin and one or two generations of cephalosporin. Conclusion: Bile infection in patients with cholecystolithiasis in Baotou area of Inner Mongolia was mainly Gram-negative bacteria and the pathogenic bacteria have a certain drug resistance to antibiotics.更多还原