【摘要】 目的探讨生发中心型(GCB)与非生发中心型(non-GCB)弥漫大B细胞淋巴瘤临床病理因素及其与预后关系。方法 98例经组织学和免疫组化确诊的弥漫大B细胞淋巴瘤患者,按照Hans免疫分型,GCB型21例(A组),non-GCB型77例(B组),比较两组生存率,分析影响预后的相关因素。结果 A组生存率高于B组(P<0.05);多因素分析显示,两组乳酸脱氢酶(LDH)水平、国际预后指数(IPI)比较差异有统计学意义(P<0.05),LDH、IPI为弥漫大B细胞淋巴瘤的独立预后因素。结论在弥漫大B细胞淋巴瘤中,non-GCB型更为常见,LDH、IPI评分是影响non-GCB型预后的主要因素,应根据患者实际情况选择合适的治疗方案。更多还原

【Abstract】 Objective To investigate relationship between clinical pathological factors and prognosis in germinal center type(GCB) and non-germinal center type(non-GCB) diffuse large B-cell lymphoma. Methods A total of 98 patients with histologically and immunohistochemically diagnosed diffuse large B-cell lymphoma were divided by Hans immunophenotyping into 21 GCB cases(group A) and 77 non-GCB cases(group B). Survival rate was compared between the two groups, and influencing factors of prognosis were analyzed. Results Group A had higher survival rate than group B(P<0.05). The difference of lactate dehydrogenase(LDH) level and international prognostic index(IPI) shown by multivariate analysis had statistical significance between the two groups(P<0.05). LDH and IPI were the independent prognosis factors for diffuse large B-cell lymphoma. Conclusion Among diffuse large B-cell lymphoma cases, non-GCB ones are common. LDH and IPI scores are main influencing factors for non-GCB prognosis. Treatment measures should be made in accordance with actual condition of patients.更多还原