【摘要】 目的探讨少见的肺多形性癌的临床病理特征。方法回顾性分析9例患者的临床资料,观察肺多形性癌的病理形态特点及免疫表型。结果患者男6例,女3例,年龄范围38~76岁,平均64.5岁;3例患者血CEA升高。肺多形性癌中含恶性上皮成分和多形性成分,即恶性梭形细胞和(或)巨细胞成分,恶性上皮成分包括腺癌、鳞状细胞癌,肿瘤细胞表达CK、EMA、CEA阳性,Vim、CK7、Napsin A、TTF-1、CK5/6和P63部分阳性。结论肺多形性癌是少见的高度恶性肿瘤,因组织学多种多样而易误诊,掌握其共同的特征性并结合临床资料方能正确诊断。更多还原

【Abstract】 Objective To introduce and discuss the clinicopathological features of pleomorphic carcinoma of the lung(PCL).Methods The clinical and pathologic findings of 9 cases of PCL were evaluated.Hematoxylin and eosin stain,immunohistochemistry and histochemistry were performed on the archival paraffin sections.Results Amongst the 9 patients,6 were males and 3 were females.Their age at the time of operation ranged from 38 to 76 years(mean=64.5 years).3 patients were with elevated plasma CEA.Microscopically,neoplastic epithelial cells and pleomorphic components,i.e.neoplasitc spindle cells and/or giant cells,were found in PCL.The malignant epithelial components included adenocarcinoma and squamous cell carcinoma.The tumor cells were positive for CK,EMA and CEA,with locally positive for Vim,CK7,NapsinA,TTF-1,CK5/6 and P63.Conclusion Pleomorphic carcinoma of the lung is a rare highly malignant tumor.They can be mistaken as other neoplasms due to the morphologic heterogeneity.Thorough understanding of the associated clinical features and laboratory investigation results is helpful in arriving at the correct diagnosis.更多还原