【摘要】 目的探讨低分子肝素联合滋肾育胎丸治疗抗心磷脂抗体阳性复发性流产的临床效果。方法选取我院2012年8月~2015年6月的172例抗心磷脂抗体阳性复发性流产患者进行药物治疗,随机分为观察组和对照组,各86例,对照组采用阿司匹林联合泼尼松治疗,观察组采用低分子肝素联合滋肾育胎丸治疗。观察两组患者的用药时间、活产率和抗体清除率等指标。结果观察组的用药时间(179.5±12.8)d明显少于对照组(288.6±14.5)d,差异有统计学意义(P<0.05);观察组活产率(91.9%)和抗体清除率(79.1%)明显高于对照组(65.1%和37.2%),差异有统计学意义(P<0.05)。观察组仅发生3例不良反应,占比3.5%,而对照组则出现15例不良反应,占比17.4%,两组比较差异有统计学意义(P<0.05)。结论对抗心磷脂抗体阳性复发性流产患者进行低分子肝素联合滋肾育胎丸治疗可以缩短治疗时间,改善妊娠结局,而且提高抗体清除率。更多还原

【Abstract】 Objective To discuss the clinical effect of low molecular weight heparin(LMWH) combined with Zishen Yutai pills in treatment of recurrent abortion with positive anticardiolipin antibody. Methods 172 patients with recurrent abortion with positive anticardiolipin antibody treated in our hospital from August 2012 to June 2015 were selected and randomly divided into observation group and control group,each group with 86 cases.Patients in the control group were treated by aspirin combined with prednisone,while patients in the observation group were treated by LMWH combined with Zishen Yutai pill.Indexes such as medication duration,live birth rate, antibody clearance rate,etc.of both groups were observed. Results The medication duration was significantly shorter in the observation group(179.5 ±12.8)d than that of control group(288.6±14.5)d,with significant difference(P<0.05).The live birth rate and antibody clearance rate were significantly higher in the observation group(91.9% and 79.1%) than that of control group(65.1% and 37.2%),with significant difference(P<0.05).There were only 3 cases(3.5%) of adverse reaction in observation group,which was significantly fewer than that of control group(15cases,17.4%)(P<0.05). Conclusion LMWH combined with Zishen Yutai pills in treatment of recurrent abortion with positive anticardiolipin antibody can shorten the medication duration, improve the pregnancy outcome,and increase the antibody clearance rate.更多还原