【摘要】 目的探讨外阴癌的临床病理因素及治疗方式对预后的影响。方法收集辽宁省肿瘤医院2004年1月至2010年6月收治的82例原发外阴癌患者的临床病例资料,对预后影响因素进行回顾性分析。结果 82例外阴癌患者中,中位年龄为55岁(29~82岁)。总的5年生存率为72%。按2009年FIGO手术病理分期,Ⅰ期40例,Ⅱ期5例,Ⅲ期24例,Ⅳ期4例,未能进行手术病理分期者9例。其中Ⅰ~Ⅱ期及Ⅲ~Ⅳ期5年生存率分别为86%、61%,两组生存率差异有统计学意义(P<0.05)。鳞癌68例,非鳞癌14例,5年生存率分别为73%、79%(P>0.05)。有病理分级报告的68例患者中G1组62例,G2~G3组6例,5年生存率分别为93%、71%(P>0.05)。79例行手术治疗,其中72例行外阴广泛性切除术及双侧腹股沟浅淋巴结切除术,术后病理无淋巴结转移48例,有淋巴结转移24例,5年生存率分别为80%、58%,两组之间生存率差异有统计学意义(P<0.05)。单纯手术组46例,手术加辅助治疗组33例,根治性放化疗组3例,5年生存率分别为72%、77%、60%,3组间差异无统计学意义(P>0.05)。结论外阴癌的5年生存率较高,临床分期、腹股沟淋巴结转移是影响外阴癌预后的不良因素。更多还原

【Abstract】 Objective To study the effect of pathologiccal factors and treatment methods of vulvar carcinoma on prognosis.Methods The data of 82 patients with vulvar carcinoma who were admitted into Liaoning Cancer Hospital from January 2004 to July 2010 were analyzed retrospectively.Results Average age of 82 cases was 55(29~82).The 5-year survival rate of vulvar carcinoma was 72%. According to FIGO 2009(surgical pathologic staging),40 cases were in stage Ⅰ,5 in stage Ⅱ,24 in stage Ⅲ,and 4 in stage Ⅳ,while 9 cases were not staged. The 5-year survival rate of StageⅠ-Ⅱ and Ⅲ-Ⅳ(P<0.05)was 86% and 61% respectively,and there was statistical difference(P<0.05).Totally 68 cases were squamous cell carcinoma,14 cases were non- squamous cell carcinoma. The five-year survival rate of them were 73% and 79%(P>0.05).The five-year survival rate of 62 cases in G1 was 93%,and that of 6 cases in G2~G3 was71%(P>0.05).In the 79 patients who received surgery,72 cases received lymphadenectomy,and 48 cases were pathologically proved with negative lymph node metastases and 24 cases positive. The 5-year survival rates of them were80% and 58% respectively and there were significantly statistical differences between them. Five-year survival rate of the 46 patients receiving surgery was 72%,that of 33 cases who were treated with surgery,chemotherapy and radiotherapy was 77%,and that 43 cases treated with chemotherapy and radiotherapy was 60%.There were no differences among them.Conclusion The 5-year survival rate of vulvar carcinoma is high,and clinical stage and lymph node metastase are important prognostic factors of vulvar carcinoma.更多还原