【摘要】 目的探讨肝原发性破骨细胞样巨细胞瘤(OGCT)的组织学来源、临床病理特征及生物学行为。方法对1例肝原发性OGCT的大体、组织学特征、免疫组化进行观察并复习相关文献。结果患者女性,41岁。右上腹痛1周。巨检:肿物大小8 cm×4.5 cm×3 cm,部分突出肝被膜;切面灰红色、质韧,部分出血、坏死及囊性变。镜检:肿物由大量的单核间质细胞及破骨细胞样巨细胞组成,出血、坏死较多。免疫组化:单核间质细胞及破骨细胞样巨细胞CD68和vimentin(+),而CK7、SMA、CK19、CK18、EMA、溶菌酶、Hep Par-1、AFP、CK20和CD34均(-),Ki-67增殖指数15%。结论肝原发性OGCT是一种非常罕见的肿瘤,其诊断和生物学行为应该结合临床病理特征、免疫组化及是否有转移等综合因素,首先要排除转移性肿瘤。更多还原

【Abstract】 Objective To investigate the histology source,clinicopathologic feature and biological behavior of primary osteoclast-like giant cell tumor( OGCT) of liver. Methods To observe general, histologic feature and immunohistochemistry of one case of primary hepatic osteoclast-like giant cell tumor of liver,and review relevant literature.Results A 41- year old woman is hospitalized after presenting with right upper abdominal pain for one week. The checked tumor size is 8 cm × 4. 5 cm × 3 cm,partly liver capsule protruding,section gray and red,tough,some hemorrhage,necrosis and cystic degeneration. Tumor by microscopic examination is composed of a large number of mononuclear stromal cells and osteoclast-like giant cells, which mainly presents with hemorrhage and necrosis.Immunohistochemistry: Mononuclear stromal cells and osteoclast-like giant cells appear CD68 and Vimentin,but CK7,SMA,CK19,CK18,EMA,lysozyme,Hep Par-1,AFP,CK20 and CD34 are negative,Ki-67 proliferation index being about 15%. Conclusion Primary OGCT of liver is a very rare tumor. Its diagnosis and biological behavior should be combined with clinicopathologic feature,immunohistochemistry and whether there are comprehensive factors such as metastasis,which eliminates metastatic tumors in the first place.更多还原