【摘要】 目的探讨结直肠癌合并2型糖尿病与淋巴结转移、肝转移的关系。方法回顾性分析170例结直肠癌患者临床资料,采用Logistic回归分析结直肠癌合并2型糖尿病与淋巴结转移、肝转移的关联性。结果 170例结直肠癌患者中同时合并2型糖尿病50例,无糖尿病120例。合并2型糖尿病组与无糖尿病组淋巴结转移率分别为52.0%和43.3%,差异无统计学意义(P>0.05);淋巴结转移度分别为17.01%和7.05%,差异有统计学意义(P<0.001)。合并2型糖尿病组肝转移率为20.0%,无糖尿病组为8.3%,差异有统计学意义(P<0.05)。进一步行Logistic回归分析未发现对结直肠癌淋巴结转移具有统计学意义的影响因素(P>0.05),而合并2型糖尿病是影响结直肠癌患者发生肝转移的独立危险因素。结论结直肠癌合并2型糖尿病患者并未增加淋巴结转移发生的危险性,但淋巴结转移数量有增加趋势,更易发生肝转移。更多还原

【Abstract】 Objective To explore whether type 2 diabetes is associated with risk of lymph node metastasis or liver metastasis in patients with colorectal cancer. Methods Medical records of 170 colorectal cancer patients were retrospectively analyzed using logistic regression to identify possible relationships of type 2 diabetes with lymph node metastasis or liver metastasis in patients with colorectal cancer. Results Of the 170 patients,50 had type 2 diabetes,while 120 did not. The rate of lymph node metastasis was 52.0% among patients with type 2 diabetes and 43.3% among those without it(P>0.05). The degeree of lymph node metastasis was 17.01% among patients with type 2 diabetes and 7.05% among those without it(P<0.001). The rate of liver metastasis was 20.0% among patients with type 2 diabetes and 8.3% among those without it(P<0.05). Logistic regression identified type 2 diabetes as an independent risk factor of liver metastasis in patients with colorectal cancer. Conclusion The presence of type 2 diabetes appears to increase risk of liver metastasis in patients with colon cancer,without affecting risk of lymph node metastasis.更多还原