【摘要】 目的:观察并分析血液灌流联合血液透析对重症急性胰腺炎患者的治疗效果。方法:选取本院2013年4月-2015年8月收治的重症急性胰腺炎患者50例作为研究对象,依照患者治疗意愿和随机数表法将患者均分为甲组和乙组各25例。两组患者均进行常规治疗,甲组患者在常规治疗基础上采取单纯血液灌流治疗,乙组在常规治疗基础上采取血液灌流联合血液透析治疗,观察两组患者血液生化检查结果变化、临床指标变化、并发症发生率、致死率及总住院时间等治疗情况。结果:治疗结束后,两组患者生化检查结果与治疗前相比均明显好转,且乙组患者检查结果改善情况明显优于甲组患者,差异具有统计学意义(P<0.05);两组患者治疗后基本生命体征均处于平稳状态,与治疗前相比改善效果明显,差异有统计学意义(P<0.05);乙组患者临床治疗效果明显优于甲组,差异具有统计学意义(P<0.05)。结论:针对重症急性胰腺炎患者采取血液灌流联合血液透析治疗方式,能够稳定、有效地清除患者血液中毒素及炎性介质,不仅可以减少患者并发症发生率,降低重症急性胰腺炎致死率,同时还可以尽快帮助患者改善临床症状,并缩短患者住院时间,治疗价值显著。更多还原

【Abstract】 Objective To observe and analyze the clinical efficacy of hemoperfusion combined with hemodialysis and its effects on blood of patients with severe acute pancreatitis. Methods 50 patients admitted to our hospital between April 2013 and August 2015 were selected as the objects of this study. Based on patients’ willingness and random number table method, the patients were divided into groups A and B, each with 25 patients. Based on the conventional therapy, group A received hemoperfusion treatment and group B received hemoperfusion combined with hemodialysis treatment. Changes in the results of blood biochemistry tests, clinical indicators, rate of complication, fatality rate and hospitalization time were observed for patients in these two groups.Results After treatment, biochemistry test results with the two groups of patients were significantly improved compared with those before treatment. Moreover, the test results of group B were improved much more than those of group A. The difference is statistically significant, P<0.05. The basic vital signs of two groups were both in a steady state after treatment, and they were improved a lot compared with those before treatment. However, the difference between these two groups was not statistically significant, P>0.05. Additionally, the clinical therapeutic efficacy of group B was much better than that of group A. The difference is statistically significant, P<0.05. Conclusions The therapeutic method of hemoperfusion combined with hemodialysis can stably and efficiently remove toxins and inflammatory mediators in the blood of patients with severe acute pancreatitis. Furthermore, the superiority of this treatment method has shown in other aspects: reducing the complication rate and fatality rate, quickly improving the clinical symptoms of patients, shortening the hospitalization time, etc. Hemoperfusion combined with hemodialysis has shown an obvious and important therapeutic value in our study, which is worthy of being widely promoted in clinics.更多还原