【摘要】 目的:探讨MTMR3基因3’非翻译区(3’UTR)1670C>T多态性与胃癌发病的关联。方法:通过病例对照研究,采用聚合酶链式反应-限制性片段长度多态性方法检测500例胃癌患者和502例正常对照者MTMR3基因1670C>T位点的基因型,通过非条件Logistic回归,并校正了性别、年龄、吸烟、饮酒的影响,分析该位点与胃癌易感性的关系。结果:MTMR3基因1670C>T基因型分布在病例组和对照组均符合Hardy-Weinberg平衡(P>0.05)。经过年龄、性别、吸烟和饮酒状况校正的非条件logistic回归分析发现,与CC基因型患者相比,含有T等位基因的基因型(CT和TT)患者胃癌的发病风险增高(校正优势比=1.72,95%置信区间=1.36~2.16,P=3.99×10-5)。结论:MTMR3基因1670C>T多态性位点与胃癌发病存在显著性关联,1670T可能是胃癌发生的一个遗传危险因素。更多还原

【Abstract】 Objective: To investigate the relationship between the polymorphism of 1670C>T in 3’-untranslated region(3’UTR) of MTMR3 and gastric cancer(GC). Methods: A case-control study was conducted. The genotypes of 1670C>T in MTMR3 were identified with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) in 500 GC cases and 502 cancer-free controls.Unconditional logistic regression, adjusted by gender, age, smoking and alcohol status, was used to analyze the association of genotypes with GC risk. Results: The genotypes of 1670C>T in MTMR3 were in Hardy-Weinberg equilibrium in both controls and cases group(P>0.05). After adjustment for age, gender, smoking status and alcohol consumption by logistic regression, the carriers of T allele genotypes(CT and TT) of MTMR3 were associated with a significantly increased risk of GC(adjusted OR=1.72, 95% CI=1.36-2.16, P=3.99×10-5),Compared with the CC wild type genotype carriers. Conclusions: The polymorphism of 1670C>T in MTMR3 is associated with GC, thus the 1670 T allele may be an inherited risk factor for GC development.更多还原