【摘要】 目的探讨25羟维生素D[25(OH)D3]与妊娠期代谢性疾病综合征(GMS)的相关性。方法选取2015年1月至2016年1月广东省妇幼保健院妇产科收集的100例确诊为妊娠期代谢综合征妇女作为GSM组,另选100例正常妊娠妇女作为对照组,检测两组妇女的血25羟维生素D及相关代谢指标,并分析其相关性。结果 GMS组的年龄、孕次、分娩次数、高密度脂蛋白(HDL-C)水平与对照组差异均无统计学意义(t值分别为0.508,1.010,1.179,1.026,P>0.05),GMS组的体质量指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、游离脂肪酸(FFA)水平均显著高于对照组(t值分别为9.284、5.572、4.480、3.192、6.184、4.317、8.689、9.360、3.070,均P<0.05),GM S组的25(OH)D3水平显著低于对照组(t=16.856,P<0.05);多因素分析法采用Logistic回归进入法进行分析,结果显示:孕期BMI、糖化血红蛋白与妊娠妇女并发GMS具有正相关关系,而25(OH)D3水平与妊娠妇女并发GMS具有负相关关系(OR值分别为1.797、1.338、-1.619,均P<0.05)。结论 25(OH)D3缺乏是妊娠期代谢性疾病综合征的独立危险因素。更多还原

【Abstract】 Objective To investigate the relationship between 25( OH) D3 and gestational metabolic syndrome( GMS). Methods From January 2015 to January 2016 one hundred women diagnosed with GMS were recruited in GMS group from the department of obstetrics and gynecology in Guangdong Maternal and Child Health Care Hospital group,and another 100 healthy pregnant women were selected in control group. Blood 25( OH) D and related metabolic parameters of the cases were detected to analyze their correlation. Results To compare age,gravidity,delivery times and HDL-C levels,the differences had no statistical significance between GMS group and the control group( t value was 0. 508,1. 010,1. 179 and 1. 026,respectively,all P > 0. 05). In the GMS group BMI,TC,TG,LDL-C,systolic blood pressure( SBP),diastolic blood pressure( DBP),fasting plasma glucose( FPG),Hb A1 c and serum free fatty acid( FFA) levels were significantly higher than those in the control group( t value was 9. 284,5. 572,4. 480,3. 192,6. 184,4. 317,8. 689,9. 360 and 3. 070,respectively,all P < 0. 05). Levels of 25( OH) D3 in cases in the GMS group were significantly lower than those in the control group( t =16. 856,P < 0. 05). Multi factor analysis with logistic regression showed that BMI in pregnancy and Hb A1 c were positively correlated with GMS but 25( OH) D3 level was negatively correlated with GMS( OR value was 1. 797,133. 8 and- 161. 9,respectively). Conclusion Deficiency of 25( OH) D3 is an independent risk factor for GMS.更多还原