【摘要】 登革病毒(Dengue virus,DENV)和基孔肯雅病毒(Chikungunya fever,CHIKV)都是虫媒病毒,具有相同的传播媒介、流行区域和季节分布。这两种病毒还会造成几乎相同的临床表现,特别是在感染的初始阶段,两者无任何可以鉴别的临床特征。而这两种病毒感染的治疗和临床管理策略是截然不同的,因此早期准确诊断是必要的。正确的诊断对于疾病监测、疫情控制、疫苗研究和药物开发非常重要。目前的检测技术,目标是检测病毒,病毒成分(抗原或核酸),或宿主的免疫产生的抗体。本文主要描述登革病毒和基孔肯雅病毒检测技术的概况,以及两者诊断技术上的研究进展。更多还原

【Abstract】 Dengue virus(DENV)and chikungunya virus(CHIKV)are arthropod- borne viruses which share the sametransmission vectors, geographical distribution, and seasonal correlation. These two viruses also cause similar clinicalpresentations, especially in the initial stages of infection, without any specific distinguishing clinical features. However, theclinical treatments and management strategies for the infections of two viruses are vastly different, and the early and accuratediagnosis is imperative. Diagnosis is also important for surveillance, outbreak control, and researches related to vaccine anddrug development. Available diagnostic tests are aimed at the detection of the virus, its viral component(antigen or nucleicacid), or the host immune antibody response. This review describes the overview of DENV and CHIKV virus detectiontechnology, and the research progress of the diagnostic technology of the two.更多还原