【摘要】 目的研究难治性强迫症(Refractory obsessive-compulsive disorder,ROCD)脑源性神经营养因子(brain derived neurotrophic factor,BDNF)血清浓度水平与认知功能的研究。方法方便选取2012年7月—2014年4月在该院就诊的41例ROCD组和57名相匹配的健康对照组为研究对象,采用耶鲁-布朗强迫量表(Yale-Brown obsessive-compulsive Scale,Y-BOCS)和成套神经心理状态评估工具(RBANS)评定患者的起病年龄、病程、Y-BOCS总分、RBANS总分等状况,用酶联免疫法测定血清BDNF的浓度水平。结果 ROCD的血清BDNF浓度水平为(1.45±0.33)ng/m L,明显比健康对照组要低(P<0.01),差异有统计学意义。认知功能中语言方面差异有统计学意义(P<0.01)。ROCD的血清BDNF浓度水平与性别、起病年龄、病程、Y-BOCS总分、RBANS总分无明显相关。结论 ROCD存在语言功能障碍,BDNF可能参与强迫症的发生。更多还原

【Abstract】 Objective To study the relationship of Refractory obsessive compulsive disorder(ROCD) BDNF serum level with cognitive function. Methods Convenient in July 2012 — April 2014 in our hospital clinic of 41 cases of match ROCD and57 cases of healthy control group as the research object, used the Yale- Brown, obsessive compulsive Scale(Y-BOCS) and complete sets of neuropsychological state evaluation tool(RBANS) to assess the patient’s condition of onset of the age, course of the disease, Y- BOCS score, enzyme league immune method for measuring the concentration of serum BDNF levels.Results The serum BDNF concentration of ROCD was(1.45± 0.33)ng/m L, which was significantly lower than that of healthy controls(P<0.01), and the difference was statistically significant. There are significant differences in cognitive function(P<0.01). The serum BDNF level of ROCD was not related to gender, onset age, course of disease, Y-BOCS total score and RBANS total score. Conclusion There are language dysfunctions in ROCD; BDNF may participate in ROCD’s occurrence.更多还原