【摘要】 目的:观察过敏性咳嗽患儿食物不耐受抗体IgG水平及血清细胞因子水平。方法:选取2013年10月至2015年6月我院收治的85例过敏性咳嗽患儿和60例健康体检儿童为研究对象。酶联免疫吸附法(ELISA)检测两组血清中14种食物过敏原特异性IgG抗体和血清白细胞介素(IL)-4、转化生长因子(TGF)-β、肿瘤坏死因子(TNF)-α和干扰素(IFN)-γ水平。结果:过敏性咳嗽患儿出现食物特异性IgG抗体者70例(阳性率为82.35%),对照组为17例(阳性率为28.33%),比较差异有统计学意义(χ~2=42.77,P<0.05)。过敏性咳嗽IgG阳性患儿血清炎性因子IL-4、TGF-β、TNF-α及IFN-γ水平均高于对照组和过敏性咳嗽IgG阴性患儿(P<0.05)。结论:过敏性咳嗽患儿食物不耐受IgG抗体及血清细胞因子水平明显异常,为该病的诊疗和预防提供依据。更多还原

【Abstract】 Objective: To observe antibody immunoglobulin(IgG) and serum levels of cytokine of allergic cough children.Methods:85 children with allergic cough children and 60 healthy children were chosen in this study.ELISA method was employed to detect food-specif-ic IgG antibodies for 14 food allergens and serum levels of interleukin(IL)-4,transforming growth factor(TGF)-β,tumor necrosis factor(TNF)-α,and Interferon(IFN)-γ. Results: Food-specific IgG antibodies was 70 cases with positive rate of 82.35%,which was higher than control groupwith 28.33% with statistical significance(χ~2=42.77,P<0.05).Serum levels of IL-4,TGF-β,TNF-α,and IFN-γ in allergic cough children withpositive IgG were obviously higher than control group and allergic cough children with negative IgG(P<0.05).Conclusion: Food intolerance IgG and serum levels of cytokine of are significantly abnormal in allergic cough children,which would provide evidences for diagnosis andtreatment and prevention of allergic cough children.更多还原