【摘要】 目的:探讨老年脑卒中患者卒中后抑郁的患病率及其危险因素。方法:选择于北京友谊医院平谷医院就诊的211例脑卒中患者,根据汉密尔顿抑郁量表(HAMD)评估结果将患者分为PSD组(HAMD≥8分)和非PSD组(HAMD<8分)。收集其相关临床资料,包括性别、年龄、合并症、脑中卒史,采用美国国立卫生研究院卒中量表(NIHSS)进行神经功能缺损评分,对上述因素进行单因素和多因素分析,寻找老年PSD的危险因素。结果:PSD患病率为19.91%(42/211例)。单因素分析显示,女性,年龄﹥70岁,合并高血压病、冠心病、高脂血症,有脑卒中史,神经功能缺损评分高,病变部位为小脑、脑干、额叶是PSD的危险因素,具有统计学意义(P<0.05);多因素分析显示,年龄,女性,合并高血压、高脂血症,有脑卒中史,NIHSS高,病变部位为PSD的独立危险因素。结论:PSD的患病率较高。年龄﹥70岁、女性、合并高血压、合并高脂血症、有脑卒中史、病变部位以及NIHSS评分高为老年PSD的独立危险因素。更多还原

【Abstract】 Objective: To observe the prevalence rate of post-stroke depression(PSD) in elderly patients with stroke, and investigate its risk factors. Methods: A total of 211 elderly stroke patients were selected who admitted in Beijing Pinggu Hospital of Friendship Hospital. According to Hamilton(HAMD) depression scale, PSD patients were divided into PSD groups(HAMD ≥ 8 scores) and non-PSD group(HAMD <8 scores). Clinical data including gender, age, comorbidities, history of cerebral stroke were collected, neurological deficiency was assessed by the US National Institutes of Health Stroke Scale(NIHSS). The risk factors for PSD were analyzed by multivariable logistic regression. Results: The prevalence rate of PSD was 19.91%(42/211 cases). Univariate analysis showed that female, age(>70), presence of hypertension, coronary, hyperlipidemia, history of cerebral stroke, higher NIHSS score, the three lesion in the cerebellum, brainstem, frontal lobe, were significant risk factors in elderly PSD patients(P<0.05). Multivariate analysis showed that age, female, hypertension, hyperlipidemia, history of cerebral stroke, lesion location and higher NIHSS score were independent risk factors for PSD in elderly patients(P<0.05). Conclusion: PSD has a high prevalence rate. Age >70, female, hypertension, hyperlipidemia, history of cerebral stroke, lesion site and high NIHSS score are independent risk factors for PSD in elderly patients.更多还原