【摘要】 目的比较氨甲环酸与纤维蛋白胶在关节置换术中应用的有效性和安全性。方法通过检索PubMed,Embase,Cochrane Library,CNKI,CBM,万方等数据库有关关节置换术应用氨甲环酸和纤维蛋白胶的文献,由2位研究者按照纳入和排除标准独立筛选文献,采用RevMan 5.2软件对提取的数据进行统计学分析。结果共纳入4个随机对照试验,2个回顾性试验,共449例患者。Meta分析结果显示:氨甲环酸与纤维蛋白胶在总失血量上差异无统计学意义[MD=-192.24,95%CI(-496.16,111.69),P=0.22],血红蛋白丢失量差异无统计学意义[MD=-0.49,95%CI(-1.19,0.20),P=0.16],输血率差异具有统计学意义[OR=0.30,95%CI(0.18,0.52),P<0.01],术后并发症差异无统计学意义[OR=1.20,95%CI(0.36,3.99),P=0.76]。结论氨甲环酸在控制关节置换术术后输血率方面比纤维蛋白胶更加有效。更多还原

【Abstract】 Objective To compare the effectiveness and safety of tranexamic acid and fibrin sealant in joint arthroplasty.Methods The literatures on the application of tranexamic acid and fibrin sealant in joint arthroplasty were retrieved from PubMed,Embase,Cochrane Library,CNKI and other internet databases.Two reviewers independently screened the literatures according to the inclusion and exclusion standard.The RevMan 5.2software was adopted to conduct the statistical analysis on the extracted data.Results Four randomized controlled trials(RCTs)and 2retrospective experiments were included,involving 449 patients.The meta analysis results showed that tranexamic acid and fibrin sealant had no statistically significant difference in total blood loss[MD=-192.24,95%CI(-496.16,111.69),P=0.22]and hemoglobin loss amount[MD=-0.49,95%CI(-1.19,0.20),P=0.16],had statistically significant difference in the blood transfusion rate[OR=0.30,95%CI(0.18,0.52),P<0.01],and had no statistically significant difference in the postoperative complications[OR=1.20,95%CI(0.36,3.99),P=0.76].Conclusion Tranexamic acid is more effective than fibrin sealant of controlling postoperative transfusion rate in joint arthroplasty.更多还原